Specialty Drug


VISMODEGIB is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat basal cell carcinoma, a type of skin cancer. Compare hedgehog pathway inhibitors.

What is Vismodegib?

Commonly Used Brand Name(s)Erivedge

Therapeutic ClassificationsAntineoplastic Agent



Blackbox WarningTOP

Oral route (Capsule)

Vismodegib can result in embryo-fetal death or severe birth defects. Animal data indicate vismodegib is embryotoxic and teratogenic. Pregnancy status should be verified 7 days prior to treatment initiation. Advise female patients of the need for contraception during and after vismodegib therapy. Advise male patients of the potential risk of vismodegib exposure through semen and recommend use of condoms with female partners of reproductive potential .


Vismodegib is used to treat metastatic basal cell carcinoma, a certain type of skin cancer that has already spread through the body. This medicine also treats advanced basal cell carcinoma that has come back after surgery or cannot be treated with radiation or surgery.

This medicine is available only with your doctor's prescription.

Proper UseTOP

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

You may take this medicine with or without food.

Swallow the capsule whole. Do break, crush, or open it.

Take this medicine at the same time each day.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules):
    • For advanced or metastatic basal cell carcinoma:
      • Adults—150 milligrams once a day.
      • Children—Use and dose must be determined by your doctor.

Missed DoseTOP

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Use & StorageTOP

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of vismodegib in the pediatric population. Safety and efficacy have not been established.


Although appropriate studies on the relationship of age to the effects of vismodegib have not been performed in the geriatric population, no geriatric-specific problems have been documented to date.

Breast FeedingTOP

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


It is very important that your doctor check your progress at regular visits for any unwanted effects or problems that may be caused by this medicine.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test 7 days before you start using this medicine to make sure you are not pregnant. Use a highly effective form of birth control to keep from getting pregnant. You should not become pregnant while you are taking this medicine and for 7 months after stopping it. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may also cause birth defects if the father is using it when his sexual partner becomes pregnant. Male patients (including those who had a vasectomy) should use condoms and spermicides as forms of birth control during sexual intercourse while taking vismodegib and for 3 months after the last dose of this medicine.

Do not donate blood or blood products while taking this medicine and for 7 months after stopping it.

For male patients: Do not donate semen while taking this medicine and for 3 months after stopping it.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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