Specialty Drug


VANDETANIB is a medicine for certain types of thyroid cancer. Compare kinase inhibitors.

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Vandetanib Side Effects

What should I watch for?

Tell your doctor or health care professional right away if you have any change in your eyesight.

You may need blood work done while you are taking this medicine. If you get diarrhea, call your doctor. You may need to have your blood work checked.

Your doctor will monitor your heart while your are taking this medicine. Be sure to keep your appointments.

This medicine can make you more sensitive to the sun. Keep out of the sun while taking this medicine and for 4 months after stopping it. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you.

Do not become pregnant while taking this medicine. Women should use effective birth control while taking this medicine and for 4 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Abdominal or stomach cramps or pain

bleeding gums

blurred vision

body aches or pain

chest pain

cloudy urine




coughing up blood

difficulty with breathing or swallowing


ear congestion


fever or chills


increased menstrual flow or vaginal bleeding

irregular heartbeat recurrent

loss of voice

muscle cramps in the hands, arms, feet, legs, or face



numbness and tingling around the mouth, fingertips, or feet


pounding in the ears

prolonged bleeding from cuts

red or black, tarry stools

red or dark brown urine

slow or fast heartbeat


sore throat

stuffy or runny nose


tightness in the chest


troubled breathing

unusual tiredness or weakness (severe)

watery or bloody diarrhea

Less common

Blue lips, fingernails, or skin

chest pain or discomfort

dilated neck veins

extreme fatigue

foreign substance into the lungs

infection from breathing

irregular breathing

irregular heartbeat

irregular, fast or slow, or shallow breathing


no breathing

swelling of the face, fingers, feet, or lower legs

weight gain




darkened urine

decreased urine output


loss of appetite


pains in the stomach, side, or abdomen, possibly radiating to the back

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach


blemishes on the skin


blistering, crusting, irritation, itching, or reddening of the skin

change in taste

cracked, dry, or scaly skin

cracks in the skin

decreased appetite

decreased vision

decreased weight


discoloration of the fingernails or toenails

dry mouth

dry skin

hair loss or thinning of the hair


increased sensitivity of the skin to sunlight

itching skin

lack or loss of strength

loosening of the fingernails

loss of heat from the body

loss of taste

muscle aches or spasms


rash with flat lesions or small raised lesions on the skin

red, swollen skin

redness or other discoloration of the skin

redness or soreness around the fingernails

severe sunburn

stomach discomfort or upset


trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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