Specialty Drug
HYLAN G-F 20 (HI lan G F 20) is used to treat osteoarthritis of the knee. It lubricates and cushions the joint, reducing pain in the knee. Compare viscosupplements.

Insurance Coverage: Many major insurance plans no longer cover Synvisc One starting in 2016. Learn More


What is Synvisc One?

Commonly Used Brand Name(s)Synvisc, Synvisc Hylan G-F, Synvisc One

Therapeutic ClassificationsCartilaginous Defect Repair Agent




Hylan polymers A and B injection is used to treat knee pain caused by osteoarthritis (OA) in patients who have already been treated with pain relievers (e.g., acetaminophen) and other non-drug treatments that did not work well.

Hylan polymers A and B is similar to a substance that occurs naturally in the joints. It works by acting like a lubricant and shock absorber in the joints and helps the joints to work properly.

This medicine is to be administered only by or under the immediate supervision of your doctor.

Proper UseTOP

A nurse or other trained health professional will give you this medicine. This medicine is given as a shot into your knee joint. It may take more than one injection for the pain to go away.

Synvisc® is given as a 3-injection regimen. It is usually given once a week and repeated after a week for a total of three injections.

Synvisc-One® is given as a single injection only.

This medicine usually comes with patient information insert. Read the information carefully and make sure you understand it efore receiving this medicine. If you have any questions, ask your doctor.

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of hylan polymers A and B injection in children up to 21 years of age. Safety and efficacy have not been established.


No information is available on the relationship of age to the effects of hylan polymers A and B injection in geriatric patients.

Breast FeedingTOP

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical ProblemsTOP

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to bird products such as poultry, feathers, or eggs or
  • Lymphatic or venous stasis (severe swelling or blood clots) in the legs—Use with caution. May make these conditions worse.
  • Allergy to products containing hyaluronan or sodium hyaluronate or
  • Skin or knee joint infections or other problems at the place where the injection is to be given—Should not be given in patients with these conditions.
  • Joint effusion (too much fluid in the knees)—Patients with this condition should be treated first before receiving this medicine.


Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

Temporary pain or swelling in the knee joint may occur after receiving the injection. Call your doctor if the pain or swelling in the knee persists or becomes worse after receiving this medicine.

Do not strain your knee joint for two days after receiving this medicine. Avoid activities such as jogging, soccer, tennis, heavy lifting, or standing on your feet for a long time.

Do not use this medicine with disinfectants containing quaternary ammonium salts (e.g., benzalkonium chloride). This may prevent hylan polymers A and B injection from working properly.

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