Specialty Drug
OMACETAXINE is a chemotherapy drug. This medicine is used to treat chronic myelogenous leukemia. Compare kinase inhibitors.

Synribo Side Effects

What should I watch for?

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

You may need blood work done while you are taking this medicine.

You may get drowsy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools

bleeding gums

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the urine or stools

bloody nose




lower back or side pain

painful or difficult urination

pale skin

pinpoint red spots on the skin

rapid weight gain

shortness of breath

sore throat

tingling of the hands or feet

troubled breathing with exertion

ulcers, sores, or white spots in the mouth

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight gain or loss

Incidence not known

Arm, back, or jaw pain

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or discomfort



decreased urination

deep, dark purple bruises

difficulty with speaking

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

double vision

dry mouth


fast, shallow breathing

fast, slow, pounding, or irregular heartbeat or pulse

flushed, dry skin

fruit-like breath odor


hives, rash, or itching, pain, redness, or swelling of the skin


inability to move the arms, legs, or facial muscles

inability to speak

increased hunger

increased thirst

increased urination


joint pain, stiffness, or swelling

loss of consciousness

muscle cramps



pale, clammy skin

pounding in the ears

rapid breathing

slow speech


sunken eyes


swelling of the eyelids, face, lips, hands, or feet


troubled breathing or swallowing

unexplained weight loss

vomiting of blood or material that looks like coffee grounds

wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abdominal or stomach pain

back pain

bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site


difficulty having a bowel movement (stool)

difficulty with moving

hair loss or thinning of the hair

lack or loss of strength

loss of appetite

muscle pain or stiffness

pain in the arms or legs

trouble sleeping

upper abdominal or stomach pain

weight loss

Incidence not known

Acid or sour stomach



bleeding gums

bloody eye

bone pain

burning, dry, or itching eyes

continuous ringing or buzzing or other unexplained noise in the ears

darkening of the skin

decreased appetite


double vision

dry skin

ear pain

eye discharge or excessive tearing

eye pain

general feeling of discomfort or illness

hearing loss


increased sweating


itching skin

muscle spasm, stiffness, or weakness

redness and swelling of the gums

redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid

stomach discomfort or upset

stuffy nose

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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