MAFENIDE is a sulfonamide antibiotic. It is used on the skin for second or third degree burns. It helps to prevent or treat serious infection. Compare sulfa antibiotics.

What is Sulfamylon?

Commonly Used Brand Name(s)Sulfamylon

Therapeutic ClassificationsAntibacterial




Mafenide, a sulfa medicine, is used to prevent and treat bacterial or fungus infections. It works by preventing growth of the fungus or bacteria.

Mafenide cream is applied to the skin and/or burned area(s) to prevent and treat bacterial or fungus infections that may occur in burns.

Other medicines are used along with this medicine for burns. Patients with severe burns or burns over a large area of the body must be treated in a hospital.

This medicine is available only with your doctor's prescription.

Proper UseTOP

To use:

  • Before applying this medicine, cleanse the affected area(s). Remove dead or burned skin and other debris.
  • Wear a sterile glove to apply this medicine. For the topical creak, apply a thin layer (about 1/16 inch) of mafenide to the affected area(s). For the topical solution, the solution is applied to the dressing covering the affected area(s). Keep the affected area(s) covered with the medicine at all times.
  • If this medicine is rubbed off the affected area(s) by moving around or if it is washed off during bathing, showering, or the use of a whirlpool bath, reapply the medicine.
  • After this medicine has been applied, the treated area(s) may be covered with a dressing or left uncovered as desired.

To help clear up your skin and/or burn infection completely, keep using mafenide for the full time of treatment. You should keep using this medicine until the burn area has healed or is ready for skin grafting. Do not miss any doses.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage form (cream):
    • For bacterial or fungus infection:
      • Adults and children 2 months of age and over—Use one or two times a day.
      • Infants and children up to 2 months of age—Use is not recommended.
  • For topical dosage form (solution):
    • For bacterial or fungus infection:
      • Adults and children 3 months of age and over—Use every 4 to 8 hours each day as needed to keep the dressing wet.
      • Infants and children up to 3 months of age—Use is not recommended.

Missed DoseTOP

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Use & StorageTOP

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Use of mafenide is not recommended in premature or newborn infants up to 2 months of age. Sulfa medicines may cause liver problems in these infants.


Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of mafenide in the elderly with use in other age groups.


Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast FeedingTOP

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Methenamine

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical ProblemsTOP

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood problems—Use of mafenide may make the condition worse.
  • Glucose-6-phosphate dehydrogenase deficiency (lack of G6PD enzyme)—Use of mafenide in persons with this condition may result in hemolytic anemia.


It is important that your doctor check your progress at regular visits.

If your skin infection or burn does not improve within a few days or if your more serious burns or burns over larger areas do not improve within a few weeks, or if they become worse, check with your doctor.

Chemical ClassificationsTOP

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