Simvastatin is an HMG-CoA reductase inhibitor or 'statin,' which lowers levels of cholesterol and triglycerides in the blood. Statins may also reduce the risk of heart attack or stroke in patients with risk factors for heart disease. Simvastatin is also available as brand name Zocor. Juvisync, which combines Januvia (sitagliptin, a diabetes medication) with simvastatin, treats both diabetes and high cholesterol.
Get the latest updates on this drug from the GoodRx medical team.
by Dr. Sharon Orrange – November 15, 2013
For the first time in a decade, the American College of Cardiology (ACC) and the American Heart Association (AHA) have made new recommendations for who we treat with statins for high cholesterol and toward what goal. The new guidelines are different. Here is what you need to know:
• Gone are the recommended LDL cholesterol targets, specifically those that ask physicians to treat patients with cardiovascular disease to less than 100 or the optional goal of less than 70. See More
by The GoodRx Pharmacist – May 15, 2013
If you are taking a statin like Lipitor (atorvastatin) or Zocor (simvastatin) you probably have been told to avoid grapefruit and grapefruit juice. You might have asked yourself—why? If so, here is your answer.
Statins are metabolized in the liver by a select group of enzymes. Grapefruit can also attach to these enzymes, which can lead to decreased statin metabolism—meaning your body won’t process the medication the way it’s supposed to. See More
by Dr. Sharon Orrange – April 23, 2013
Lifelong treatment with a medication is a tall order for some people. So it is not surprising that discontinuation rates are high for the cholesterol medications, the “statin” drugs.
Despite their benefits, statin drugs are commonly discontinued. Serious side effects like rhabdomyolysis (breakdown of muscle fibers) and liver test abnormalities are very rare. Many patients know that statins have been reported to cause muscle pain, and because everyone has muscle pain or joint pain from time to time, blaming the medication is a natural tendency. See More
by Elizabeth Davis – March 28, 2013
When it comes to saving on your prescriptions, sometimes the way to get the best price isn’t as straightforward as simply using a coupon or switching to a generic.
Recently, I visited a doctor to try and figure out why I was having headaches. It took months, but eventually I was diagnosed with migraines; then, I had to work with my doctor to find the right medication to manage the migraines.
Like many Americans, I have health insurance, but even with insurance, the cost of my drugs was giving me a headache. See More
by Dr. Sharon Orrange – February 04, 2013
If you take prescription drugs to treat a chronic illness, it’s possible to save more than 50% off cost of your medication by simply splitting your pills.
Sadly, it’s not all that easy to know when pill splitting is all right.
Not all pills can be split. However, many doctors and insurance companies are advising this strategy with an increasing number of medicines. (It’s also worth noting that the American Medical Association, the American Pharmacists Association, and most pharmaceutical companies oppose pill-splitting. See More
by Dr. Sharon Orrange – January 30, 2013
Aside from Zetia there haven’t been any good non-statin options for lowering LDL Cholesterol. Statin drugs like Lipitor (atorvastatin), Zocor (simvastatin) and Crestor work well to lower the “bad” cholesterol, the LDL, and have remained first line therapy for many years. Finally, there may be something new to get excited about. But, it does have some “issues.”
by Dr. Sharon Orrange – May 02, 2012
Nocturnal leg cramps are a common cause of pain in the legs that can disrupt sleep. They are present in nearly 50 percent of those over the age of 50. Leg cramps are characterized by sudden muscle tightness, most commonly in the foot, thigh, or calf, that may last from seconds to minutes. Forceful stretching of the affected muscles usually relieves these leg cramps. For some reason, the vast majority of people have these cramps only at night. See More
by Dr. Sharon Orrange – March 20, 2012
For years, patients taking statin drugs have complained of a fuzzy head and less clear thinking. Statins, the cholesterol lowering medications, are among the most prescribed medications and include simvastatin (Zocor), atorvastatin (Lipitor), pravastatin (Pravachol), Crestor (rosuvastatin), and Vytorin (ezetimibe and simvastatin).
While studies have not shown statins to cause memory impairment, the FDA has decided to listen to patients and add a warning on the label of statin drugs. See More
by Dr. Sharon Orrange – January 20, 2012
Whether you take atorvastatin (Lipitor), simvastatin (Zocor), or Crestor (rosuvastatin), the statins have a very similar risk and benefit profile. Here are answers to the top questions I am asked about statin drugs by my patients:
1. Will they hurt my liver? Liver test abnormalities occur in less than 1 in 100 patients taking statin drugs and resolve if you stop the medication. If the liver tests (AST and ALT) are greater than 3 times normal we stop your statin drug. See More
by Dr. Sharon Orrange – January 11, 2012
A new combination pill targeted at diabetes and cholesterol is hitting the market and you will be hearing about it. Juvisync is a combination medication that contains two previously approved medicines: the generic cholesterol medication simvastatin, and Januvia (sitagliptin) a diabetes medication.
What are the upsides of Juvisync?
1) First off, you kill two birds with one stone and treat diabetes and cholesterol in one pill. See More
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