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Sargramostim
Specialty Drug

Leukine

SARGRAMOSTIM, GM-CSF (sar GRAM oh stim) helps the body make more blood cells. It is used to increase the number of blood cells after chemotherapy or with a blood or bone marrow transplant. Compare leukocyte growth factors.
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What is Sargramostim?

Commonly Used Brand Name(s)Leukine

Therapeutic ClassificationsHematopoietic

Pharmacologic ClassificationsColony Stimulating Factor

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OverviewTOP

Sargramostim is a synthetic (man-made) version of a substance that is naturally produced in your body called a colony stimulating factor. It helps the bone marrow to make new white blood cells .

When certain cancer medicines are used to fight cancer cells, they also affect the white blood cells that fight infections. Sargramostim is used to prevent or reduce the risk of infection while you are being treated with cancer medicines. This medicine is also used to help the bone marrow recover after a bone marrow transplantation, and for a process called peripheral blood progenitor cell collection in cancer patients .

This medicine is available only with your doctor's prescription .

Proper UseTOP

A nurse or other trained health professional may give you this medicine. Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins .

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

AllergiesTOP

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

PediatricTOP

Appropriate studies performed to date have not demonstrated pediatrics-specific problems that would limit the usefulness of sargramostim in children. However, safety and efficacy have not been established in babies younger than 4months of age .

GeriatricTOP

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of sargramostim in the elderly .

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical ProblemsTOP

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bone marrow hyperplasia—Should not be used. Will result to higher risk of serious side effect in patients with this condition .
  • Congestive heart failure or
  • Edema (fluid retention) or
  • Heart disease or
  • Heart rhythm problems, history of or
  • Hypoxia (decreased oxygen in the tissues) or
  • Kidney disease or
  • Liver disease or
  • Lung disease or breathing problems or
  • Pericardial effusion (fluid around the heart) or
  • Pleural effusion (fluid around the lungs)—Use with caution. May make these conditions worse .

PrecautionsTOP

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects .

Tell your doctor about all the other medicines you are using, especially if you are being treated for cancer. This medicine should not be given at the same time as chemotherapy or radiotherapy or within 24 hours before or after you receive your cancer treatment .

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