RIFAPENTINE is an antibiotic. It is used to treat of tuberculosis (TB). This medicine is never used alone for tuberculosis, but in combination with at least one other agent. Compare rifamycin / antimycobacterial combinations.

Rifapentine Side Effects

What should I watch for?

Visit your doctor or health care professional for regular checks on your progress. You will need to have blood work done regularly while you are taking this medicine. This medicine can cause serious liver problems. Make sure you understand the risks for liver problems and how to identify the symptoms. If you have any questions, talk with your doctor or other health care provider.

Avoid alcoholic drinks while you are taking this medicine. Drinking alcohol during treatment with this medicine increases the risk of serious liver problems.

Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery.

You may need to take a vitamin B6 supplement while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care professional.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.

Antacids may reduce the absorption of this medicine. Doses of this medicine should be given at least 1 hour before taking antacids.

This medicine can color your urine, feces (stool), perspiration (sweat), tears, sputum, skin or saliva reddish-orange to reddish-brown. This color can last for as long as you take this medicine and is not a cause for alarm. This color in tears may permanently stain soft contact lenses. It is better not to wear soft contact lenses while you are taking this medicine. This medicine may stain dentures.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Blood in the urine

joint pain

lower back or side pain

swelling of the feet or lower legs

Less common

Aggressive reaction

black, tarry stools

blood in the stools


pinpoint red spots on the skin

severe abdominal or stomach pain

sore throat and fever

unusual bleeding or bruising

unusual tiredness or weakness


yellow eyes or skin




increase in blood pressure

severe or continuing headaches

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common



loss of appetite

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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