Specialty Drug


LENALIDOMIDE is a chemotherapy drug that targets specific proteins within cancer cells and stops the cancer cell from growing. It is used to treat multiple myeloma, mantle cell lymphoma, and some myelodysplastic syndromes that cause severe anemia requiring blood transfusions. Compare thalidomides.

Revlimid Side Effects

What should I watch for?

Visit your doctor for regular check ups. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. You will need to have important blood work done while you are taking this medicine.

This medicine is available only through a special program. Doctors, pharmacies, and patients must meet all of the conditions of the program. Your health care provider will help you get signed up with the program if you need this medicine. Through the program you will only receive up to a 28 day supply of the medicine at one time. You will need a new prescription for each refill.

This medicine can cause birth defects. Do not get pregnant while taking this drug. Females with child-bearing potential will need to have 2 negative pregnancy tests before starting this medicine. Pregnancy testing must be done every 2 to 4 weeks as directed while taking this medicine. Use 2 reliable forms of birth control together while you are taking this medicine and for 1 month after you stop taking this medicine. If you think that you might be pregnant talk to your doctor right away.

Men must use a latex condom during sexual contact with a woman while taking this medicine and for 28 days after you stop taking this medicine. A latex condom is needed even if you have had a vasectomy. Contact your doctor right away if your partner becomes pregnant. Do not donate sperm while taking this medicine and for 28 days after you stop taking this medicine.

Do not give blood while taking the medicine and for 1 month after completion of treatment to avoid exposing pregnant women to the medicine through the donated blood.

Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Black, tarry stools

bleeding gums

blood in the urine or stools

chest pain




decreased urine

difficult or labored breathing

dry mouth


increased thirst

irregular heartbeat

loss of appetite

lower back or side pain

mood changes

muscle pain or cramps

nausea or vomiting

numbness or tingling in the hands, feet, or lips

painful or difficult urination

pale skin

pinpoint red spots on the skin

sore throat

sores, ulcers, or white spots on the lips or in the mouth

swollen glands

tightness in the chest

unusual bleeding or bruising

unusual tiredness or weakness

Less common

Chest discomfort


difficulty with speaking

double vision


inability to move the arms, legs, or facial muscles

inability to speak

pain or discomfort in the arms, jaw, back or neck

slow speech


Incidence not known


blistering, peeling, or loosening of the skin

clay-colored stools

dark-colored urine

depressed mood


difficulty having a bowel movement (stool)

dizziness or lightheadedness

dry skin and hair


fast heartbeat

feeling cold

general feeling of tiredness or weakness

hair loss

hoarseness or husky voice

itching or rash

joint pain, stiffness, or swelling

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

muscle cramps and stiffness

pain, redness, or swelling in the arm or leg

red skin lesions, often with a purple center

red, irritated eyes

sensitivity to heat

slowed heartbeat

stomach pain, continuing

sudden shortness of breath or troubled breathing

swelling of the feet or lower legs

trouble sleeping

unpleasant breath odor

vomiting of blood

weight gain or loss

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abnormal or decreased touch sensation

bloody nose

blurred vision

body aches or pain


burning while urinating

burning, numbness, tingling, or painful sensations

change in taste

cough-producing mucus

difficulty with moving

drowsiness or tiredness

ear congestion

fast, slow, irregular, pounding, or racing heartbeat or pulse

flushing or redness of the skin

increased sweating or night sweats


itching, pain, redness, swelling, tenderness, or warmth on the skin

lack or loss of strength

large, flat, blue or purplish patches in the skin

loose stools

loss of interest or pleasure

muscle spasms, stiffness, or twitching

pain or tenderness around the eyes and cheekbones



tender, swollen glands in the neck


trouble concentrating

trouble swallowing

unsteadiness or awkwardness

upper abdomen or stomach pain

voice changes

weakness in the arms, hands, legs, or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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