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Regorafenib
Specialty Drug

Stivarga

REGORAFENIB is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat colorectal cancer and gastrointestinal stromal tumors (GIST). Compare kinase inhibitors.
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Regorafenib Side Effects

What should I watch for?

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

You may need blood work done while you are taking this medicine.

Do not become pregnant while taking this medicine or for 2 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 2 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

If you are going to have surgery or any other procedures, tell your doctor you are taking this medicine.

Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.

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Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Bleeding gums

blurred vision

cough or hoarseness

coughing up blood

difficulty with breathing or swallowing

dizziness

fever or chills

headache

increased menstrual flow or vaginal bleeding

lower back or side pain

nervousness

nosebleeds

painful or difficult urination

pounding in the ears

prolonged bleeding from cuts

rash

red or black, tarry stools

redness, swelling, or pain of the skin

scaling of the skin on the hands and feet

slow or fast heartbeats

tingling of the hands and feet

ulcers on the skin

Less common

Chest pain or discomfort

dark-colored urine

general feeling of tiredness or weakness

light-colored stools

nausea or vomiting

pain or discomfort in the arms, jaw, back, or neck

shakiness in the legs, arms, hands, or feet

stomach pain that continues

sweating

yellow eyes or skin

Rare

Confusion

heartburn

indigestion

severe stomach pain, cramping, or burning

vomiting of material that looks like coffee grounds

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bad, unusual, or unpleasant taste

hair loss or thinning of the hair

lack or loss of strength

muscle or joint stiffness

weight loss

Less common

Constipation

depressed mood

dry skin and hair

feeling cold

muscle cramps

weight gain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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