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Raltegravir Coupon - Raltegravir 400mg tablet
Raltegravir

Isentress

RALTEGRAVIR is an antiretroviral medicine. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. It will not stop the spread of HIV to others. Compare HIV integrase strand transfer inhibitors.
Raltegravir Coupon - Raltegravir 400mg tablet
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What is Raltegravir?

Commonly Used Brand Name(s)Isentress

Therapeutic ClassificationsAntiretroviral Agent

Pharmacologic ClassificationsIntegrase Inhibitor

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OverviewTOP

Raltegravir is used together with other medicines for the treatment of the infection caused by human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS). This medicine is usually given to patients who have already received HIV medicines in the past.

Raltegravir will not cure or prevent HIV infection or AIDS; however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay the development of problems that usually result from AIDS or HIV disease. Raltegravir will not keep you from spreading HIV to other people. People who receive this medicine may continue to have some of the problems usually related to AIDS or HIV disease.

This medicine is available only with your doctor's prescription.

Proper UseTOP

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not change the dose or stop taking this medicine without checking first with your doctor. When your supply of this medicine is running low, contact your doctor or pharmacist ahead of time. Do not allow yourself to run out of this medicine.

This medicine comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Keep taking raltegravir for the full time of treatment, even if you begin to feel better. It is also important to take this medicine together with other medicines for HIV. Be sure to take all of the medicines your doctor ordered, and to take them at the right times.

You may take this medicine with or without food.

You may chew or swallow the chewable tablets whole. However, the film-coated tablets must be swallowed whole.

If you are using the oral suspension:

  • Pour the contents of one single-use packet in 5 milliliters (mL) of water and mix.
  • Use the dosing syringe that comes with the package to measure the right dose.
  • The dose should be taken within 30 minutes after mixing the suspension.
  • Throw away any remaining suspension.

Do not substitute the chewable tablets or oral suspension with the film-coated tablets. Ask your doctor or pharmacist if you have any questions.

DosingTOP

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For treatment of HIV infection:
    • For oral dosage form (chewable tablets):
      • Children weighing at least 25 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. The dose is usually 150 milligrams (mg) two times a day. However, the dose is usually not more than 300 mg two times a day.
      • Children weighing less than 25 kg—Dose is based on body weight and must be determined by your doctor. The dose is usually 75 to 150 mg two times a day.
      • Children 4 weeks of age and older and weighing less than 11 kg—Use of oral suspension is recommended.
      • Children younger than 4 weeks of age—Use and dose must be determined by your doctor.
    • For oral dosage form (film-coated tablets):
      • Adults, teenagers, and children 12 years of age and older—400 milligrams (mg) two times a day.
      • Children weighing at least 25 kilograms (kg)—400 mg two times a day.
      • Children weighing less than 25 kg—Use of chewable tablets are recommended.
      • Children 4 weeks of age and older and weighing less than 11 kg—Use of oral suspension is recommended.
      • Children younger than 4 weeks of age—Use and dose must be determined by your doctor.
    • For oral dosage form (suspension):
      • Children 4 weeks of age and older and weighing less than 25 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. The dose is usually 1 milliliter (mL) (20 mg) to 5 mL (100 mg) two times a day.
      • Children younger than 4 weeks of age—Use and dose must be determined by your doctor.

Missed DoseTOP

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Use & StorageTOP

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the chewable tablets in its original package with the bottle tightly closed. Do not open the foil packet of powder for suspension until you are ready to use it.

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

AllergiesTOP

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

PediatricTOP

Appropriate studies have not been performed on the relationship of age to the effects of raltegravir in children younger than 4 weeks of age. Safety and efficacy have not been established.

GeriatricTOP

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of raltegravir in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving raltegravir.

PregnancyTOP

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast FeedingTOP

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aluminum Carbonate, Basic
  • Aluminum Hydroxide
  • Aluminum Phosphate
  • Amprenavir
  • Dihydroxyaluminum Aminoacetate
  • Dihydroxyaluminum Sodium Carbonate
  • Fosamprenavir
  • Magaldrate
  • Magnesium Carbonate
  • Magnesium Hydroxide
  • Magnesium Oxide
  • Magnesium Trisilicate

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical ProblemsTOP

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Liver disease, severe—Use with caution. This medicine has not been studied in patients with severe liver problems.
  • Muscle weakness, pain, or tenderness, history of—Use with caution. May make these conditions worse. or
  • Phenylketonuria (PKU)—The chewable tablet contains phenylalanine, which can make this condition worse.

PrecautionsTOP

It is very important that your doctor check your or your child's progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Serious skin and allergic reactions can occur with this medicine. These could be life-threatening and require immediate medical attention. Check with your doctor right away if you have a severe rash, blistering, peeling, or loose skin, fever or chills, muscle or joint pain, sores or ulcers on the skin, swelling of the face, lips, tongue, or throat, unusual tiredness or weakness, or yellow eyes or skin while you or your child are using this medicine.

Your immune system may get stronger when you start taking HIV medicines. Tell your doctor right away if you or your child notice any changes in your health. Sometimes the immune system will start to fight infections that were hidden in your body, such as pneumonia or tuberculosis, or may result a flare-up of a hidden autoimmune disorder (eg, Graves' disease, polymyositis, Guillain-Barré syndrome).

Tell your doctor right away if you or your child have unexplained muscle pain, tenderness, or weakness, especially if you also have unusual tiredness or a fever. These could be symptoms of a serious muscle problem called myopathy.

Check with your doctor right away if you or your child have dark-colored urine, fever, muscle cramps or spasms, muscle pain or stiffness, or unusual tiredness or weakness. These could be symptoms of a serious muscle problem called rhabdomyolysis, which can cause kidney problems.

This medicine will not keep you from giving HIV to your partner during sex. Make sure you understand this and practice safe sex, even if your partner also has HIV, by using a latex condom or other barrier method. This medicine will also not keep you from giving HIV to other people if they are exposed to your blood. Do not re-use or share needles with anyone.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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