ZICONOTIDE is a non-narcotic pain reliever. It is used to treat severe chronic pain. Compare conotoxins.

Prialt Side Effects

What should I watch for?

Tell your doctor or health care professional if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may need blood work done while you are taking this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common


being forgetful

change in walking and balance

changes in patterns and rhythms of speech

clumsiness or unsteadiness


decrease in the frequency of urination

decrease in urine volume



difficulty in passing urine (dribbling)

difficulty with speaking

feeling unusually cold

painful urination

problems with speech or speaking

seeing, hearing, or feeling things that are not there

shakiness and unsteady walk

shakiness in the legs, arms, hands, or feet


slurred speech

thoughts of killing oneself

trembling or shaking of the hands or feet

uncontrolled eye movements

unsteadiness, trembling, or other problems with muscle control or coordination

Less common

Aggressive or angry

chest pain


confusion as to time, place, or person



dark-colored urine




fast heartbeat

fearfulness, suspiciousness, or other mental changes

feeling that others are watching you or controlling your behavior

feeling that others can hear your thoughts


general feeling of illness

holding false beliefs that cannot be changed by fact


muscle spasm or jerking of all extremities

muscle stiffness

rapid, shallow breathing

severe mood or mental changes

shortness of breath


sore throat

stiff neck or back

tightness in the chest

troubled breathing

trouble in concentration

trouble in sleeping

unusual behavior unusual excitement, nervousness, or restlessness

unusual tiredness or weakness



Actions that are out of control

changes in behavior


talking, feeling, and acting with excitement

Incidence not known

Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Decreased awareness or responsiveness

severe sleepiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Blurred vision

crawling feelings



dizziness or lightheadedness

excessive muscle tone, tension, or tightness

feeling of constant movement of self or surroundings



lack or loss of strength

loss of appetite

loss of memory


pain in the arms or legs

problems with memory

sensation of spinning

sleepiness or unusual drowsiness


weight loss

Less common

Acid or sour stomach

back pain

bad, unusual, or unpleasant (after) taste


bladder pain

bloody or cloudy urine


change in taste



continuing ringing or buzzing or other unexplained noise in the ears





difficulty seeing at night

difficulty with moving

double vision

dry mouth

dry skin




frequent urge to urinate

hearing loss



increased sensitivity of the eyes to sunlight

increased sensitivity to pain or touch


loss of bladder control

loss of taste

lung disorder

nerve pain

pain in the joints

pain or tenderness around the eyes and cheekbones

pale skin

pounding in the ears

quick to react or overreact emotionally

rapidly changing moods

red, scaly, swollen, or peeling areas of the skin

redness or pain at the catheter site

runny nose

severe muscle stiffness

shortness of breath or troubled breathing


slow or fast heartbeat

stomach discomfort, upset, or pain

stuffy nose


swelling or redness in the joints

tender, swollen glands in the neck

tightness of the chest or wheezing

trouble with swallowing

unusual bleeding or bruising

unusual tiredness or weakness

voice changes

warmth on the skin

weakness or heaviness in the legs

Incidence not known

Burning sensation on the skin

flaking and falling off of skin

skin blisters

sores on the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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