PEGAPTANIB is a drug that is injected into the eye. It is used to treat macular degeneration. This treatment results in a slowing of the disease and helps to maintain vision. It is not a cure. Compare VEGF antibodies.

Pegaptanib Side Effects

What should I watch for?

Your eye doctor will monitor the effects of this medicine closely. You may need to return to the office between 2 and 7 days after the treatment for a check on your condition and your response to the treatment.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Bladder pain


bloody eye

bloody or cloudy urine

blurred vision

burning, dry, or itching eyes

cough producing mucus

decreased vision or other changes in vision

difficult, burning, or painful urination

difficulty breathing

discharge, excessive tearing

disturbed color perception

double vision

drainage from eyes

eye pain

frequent urge to urinate

gradual loss of vision

halos around lights

itching of eyelid

looking through water

lower back or side pain


night blindness

overbright appearance of lights

painful irritation of the clear front part of the eye

redness, pain, swelling of eye, eyelid, or inner lining of eyelid

seeing flashes or sparks of light

seeing floating spots before the eyes

shortness of breath

sore eyes

swelling of the eye

tightness in chest

tunnel vision



Less Common

Bigger, dilated, or enlarged pupils (black part of the eye)

change in vision not present before treatment

chest pain


decrease in frequency of urination

decrease in urine volume

difficulty in passing urine (dribbling)

dizziness or lightheadedness

dry mouth

eye irritation


feeling of constant movement of self or surroundings

flushed, dry skin

fruit-like breath odor


hearing loss

inability to speak

increased hunger

increased sensitivity of eyes to light

increased thirst

increased urination

loss of consciousness

numbness or tingling in face, arms, or legs

seeing floaters, veil or curtain appearing across part of vision


sensation of spinning

severe or sudden headache

slurred speech



temporary blindness

trouble speaking, thinking, or walking

troubled breathing

unexplained weight loss

weakness in arm and/or leg on one side of the body, sudden and severe

Incidence not determined

Difficulty swallowing

fast heartbeat



puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

skin rash

unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common


Less common

Acid or sour stomach


blistering, burning, crusting, dryness, or flaking of skin


difficulty in moving



itching, scaling, severe redness, soreness, swelling of skin

muscle pain or stiffness

pain, swelling, or redness in joints

stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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