Generic Eloxatin

OXALIPLATIN is a chemotherapy drug. It targets fast dividing cells, like cancer cells, and causes these cells to die. This medicine is used to treat cancers of the colon and rectum, and many other cancers. Compare platinum-based drugs.

Oxaliplatin Side Effects

What should I watch for?

Your condition will be monitored carefully while you are receiving this medicine. You will need important blood work done while you are taking this medicine.

This medicine can make you more sensitive to cold. Do not drink cold drinks or use ice. Cover exposed skin before coming in contact with cold temperatures or cold objects. When out in cold weather wear warm clothing and cover your mouth and nose to warm the air that goes into your lungs. Tell your doctor if you get sensitive to the cold.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Call your doctor or health care professional if you get diarrhea. Do not treat yourself.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Abnormal tongue sensation

black, tarry stools

bleeding gums

blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet

blood in the urine or stools

burning, prickling, itching, or tingling of the skin

chest pain



decreased feeling, or pain in the hands, feet, around the mouth, or throat

decreased urination

difficulty performing daily activities such as writing, buttoning, swallowing, or walking

difficulty with articulating words

difficulty with breathing

difficulty with moving

difficulty with swallowing


dry mouth

eye pain



increase in heart rate

jaw spasm


muscle pain or stiffness


numbness, pain, tingling, or unusual sensations in the palms of the hands or bottoms of the feet

pain in the chest, groin, or legs, especially the calves

pain in the joints

painful or difficult urination

pale skin

pinpoint red spots on the skin

rapid breathing

sensation of pins and needles

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stabbing pain

sunken eyes


swelling or inflammation of the mouth

swollen glands


troubled breathing with exertion

unusual tiredness or weakness

vision changes

wrinkled skin

Less common

Fast heartbeat

hives, itching, or skin rash

increased thirst

irregular heartbeat

loss of appetite

mood changes

nausea or vomiting

numbness or tingling in the hands, feet, or lips

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

tightness in the chest

Incidence not known

Back, leg, or stomach pains


bloated abdomen

blue-yellow color blindness

blurred vision

changes in patterns and rhythms of speech

dark urine


decreased vision

deep breathing


electric shock-like sensation that moves down the back and into the legs following a bending movement of the neck

general body swelling

increased urination

irregular heartbeat, recurrent

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

loss of deep tendon reflexes

muscle cramps or spasms

muscle tremors

pain and fullness in the right upper abdomen


severe constipation

severe diarrhea

severe nosebleeds

severe stomach cramps or tenderness

severe vomiting

trouble with speaking

twitches of the muscle visible under the skin

weakness of the muscles in your face

weight gain

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose



cough or hoarseness



involuntary, rapid, or rhythmic movement of the eyes

lack of coordination

lack of sensation


lower back or side pain


respiratory failure


severe weakness

slow or irregular heartbeat


vomiting, profuse

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach


body aches or pain

ear congestion

feeling unusually cold, shivering




loss of voice

nasal congestion

runny nose


stomach discomfort, upset, or pain

trouble sleeping

weight loss

Less common

Bad, unusual, or unpleasant (after) taste

bloated or full feeling

bloody nose

burning while urinating

change in taste


cracked lips

dryness or soreness of the throat

excess air or gas in stomach or intestines

feeling of warmth

hair loss

passing gas

rapid weight gain

redness of the face, neck, arms, and occasionally upper chest

tender, swollen glands in the neck

thinning of the hair

unusual tearing of the eyes

voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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