Specialty Drug
Onsolis is part of the Opioids class and treats Pain. Opioids are used to treat pain, opioid dependence, and diarrhea. They work by affecting areas of the brain that sense pain and by allowing more fluid to be absorbed in the small intestine. Onsolis is only available as a brand name drug. Compare opioids.

Onsolis Side Effects

Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Black, tarry stools

blurred vision

chest pain




decreased urine

difficult or labored breathing


dry mouth


fever or chills

increased thirst

irregular heartbeat


loss of appetite

lower back or side pain

mood changes

muscle pain or cramps

nausea or vomiting


numbness or tingling in the hands, feet, or lips

painful or difficult urination

pale skin

pounding in the ears

rapid breathing


sore throat

sunken eyes

swelling of the hands, ankles, feet, or lower legs

tightness in the chest

troubled breathing with exertion

ulcers, sores, or white spots in the mouth

unusual bleeding or bruising

unusual tiredness or weakness

wrinkled skin

Less common

Abdominal or stomach pain

change in walking and balance

clumsiness or unsteadiness

decreased awareness or responsiveness

decreased frequency of urination


muscle twitching or jerking

pounding in the ears

rhythmic movement of the muscles

seeing, hearing, or feeling things that are not there


severe constipation

severe sleepiness

shakiness in the legs, arms, hands, or feet

slow or fast heartbeat

thinking abnormalities

trembling or shaking of the hands or feet

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Extremely shallow or slow breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain


difficulty having a bowel movement (stool)

difficulty with moving


feeling sad or empty


lack or loss of strength

loss of interest or pleasure

muscle stiffness

pain in the joints

sleepiness or unusual drowsiness


trouble concentrating

trouble sleeping

weight loss

Less common

Changes in vision

excessive muscle tone

feeling of constant movement of self or surroundings

feeling of warmth or heat

flushing or redness of the skin, especially on the face and neck

irritation, pain, or sores at the site of application

itching skin

muscle tension or tightness


sensation of spinning


Incidence not known

Tooth pain

trouble with gums

trouble with teeth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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