OFATUMUMAB is a monoclonal antibody. It is used to treat chronic lymphocytic leukemia (CLL). Compare monoclonal antibodies.

Ofatumumab Side Effects

What should I watch for?

This medicine can cause serious allergic reactions such as changes in your breathing, fever, chills, dizziness or lightheadedness. These effects are more common with the first dose. To reduce your risk you may need to take medicine before treatment with this medicine. Take your medicine as directed.

Visit your prescriber or health care professional for checks on your progress. You will need to have regular blood work. Report any other side effects. The side effects of this medicine can continue after you finish your treatment. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools

bloating or swelling of the face, arms, hands, lower legs, or feet

blurred vision

body aches or pain

chest pain



cough or hoarseness

cough producing mucus

difficult or labored breathing


dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

ear congestion

facial swelling


fast heartbeat

feeling of warmth


hives or welts, itching, or skin rash

increased sweating


loss of voice

lower back or side pain

nasal congestion

nausea or vomiting

painful blisters on the trunk of the body

painful or difficult urination

pale skin

rapid weight gain

rapid, shallow breathing

redness of the face, neck, arms, and occasionally, upper chest

runny nose


sore throat

tightness in the chest

tingling of the hands or feet

troubled breathing

troubled breathing with exertion

ulcers, sores, or white spots in the mouth

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight gain or loss


Less common

Fast, pounding, or irregular heartbeat or pulse


pounding in the ears

slow heartbeat

Incidence not known

Blistering, peeling, or loosening of the skin

dark urine


fluid-filled skin blisters

joint or muscle pain

light-colored stools

no blood pressure or pulse

red skin lesions, often with a purple center

red, irritated eyes

sensitivity to the sun

skin thinness

stopping of heart


yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain

muscle aches

redness of the skin

trouble sleeping

Less common

Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

muscle spasms

pain or tenderness around the eyes and cheekbones

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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