ETONOGESTREL is a contraceptive (birth control) device. It is used to prevent pregnancy. It can be used for up to 3 years. Compare progestins.

Nexplanon Side Effects

What should I watch for?

This product does not protect you against HIV infection (AIDS) or other sexually transmitted diseases.

You should be able to feel the implant by pressing your fingertips over the skin where it was inserted. Contact your doctor if you cannot feel the implant, and use a non-hormonal birth control method (such as condoms) until your doctor confirms that the implant is in place. If you feel that the implant may have broken or become bent while in your arm, contact your healthcare provider.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Breast pain





general feeling of discomfort or illness


joint pain

loss of appetite

muscle aches and pain


runny nose


sore throat


trouble sleeping

unusual tiredness or weakness


Less common

Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site


blurred vision or other changes in vision

breast discharge

breast enlargement

burning while urinating

difficult or painful urination

difficulty with breathing

difficulty with swallowing


fast heartbeat

headache, severe and throbbing



lumps in the breasts


noisy breathing

painful or tender cysts in the breasts

pounding in the ears

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

shortness of breath

skin rash

slow or fast heartbeat

stomach or pelvic discomfort, aching, or heaviness

swelling of the hands, ankles, feet, or lower legs

tightness in the chest



Collection of blood under the skin at the injection site

deep, dark purple bruise at the injection site

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain

blemishes on the skin, pimples

body aches or pain





ear congestion


feeling sad or empty


increased clear or white vaginal discharge

increased weight

irregular bleeding cycle


itching of the vagina or genital area

light vaginal bleeding between regular menstrual periods

loss of interest or pleasure

loss of voice

mental depression

nasal congestion

pain, cramps, or heavy menstrual bleeding

pain during sexual intercourse

pain or tenderness around the eyes and cheekbones


quick to react or overreact emotionally

rapidly changing moods

stomach pain

tender, swollen glands in the neck

thick, white vaginal discharge with no odor or with a mild odor

trouble concentrating

voice changes

Less common

Abdominal or stomach bloating and cramping

abnormal ejaculation

abnormal or decreased touch sensation

acid or sour stomach


bone pain

burning feeling in the chest or stomach

decreased interest in sexual intercourse

difficulty having a bowel movement (stool)

difficulty with moving

dull ache or feeling of pressure or heaviness in the legs

earache, redness, or swelling in the ear

excess air or gas in the stomach or intestines

feeling of vaginal pressure

feeling of warmth

hair loss or thinning of the hair


inability to have or keep an erection

increased appetite

increased hair growth on the forehead, back, arms, and legs


itching skin near damaged veins

lack or loss of strength

loss in sexual ability, desire, drive, or performance

muscle cramping or stiffness

passing gas

pelvic pain

redness of the face, neck, arms, and occasionally upper chest

sleepiness or unusual drowsiness



stomach upset or pain

stuffy nose

swollen joints

tenderness in the stomach area

unable to sleep

vaginal burning or pain

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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