NEOSTIGMINE can help to correct muscle strength. It is used to treat myasthenia gravis. Compare cholinesterase inhibitors.

Neostigmine Methylsulfate Side Effects

What should I watch for?

Visit your doctor or health care professional for regular checks on your progress. Tell your doctor if your symptoms do not improve or if they get worse.

Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Blurred or loss of vision

chest pain, discomfort, or tightness


difficult or labored breathing

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

fast, slow, pounding, or irregular heartbeat or pulse

lightheadedness, dizziness, or fainting


twitches of the muscle visible under the skin

unusual tiredness or weakness

Incidence not known

Changes in patterns and rhythms of speech


difficulty in moving

difficulty swallowing

disturbed color perception

double vision

halos around lights


irregular, fast or slow, or shallow breathing


loss of consciousness

muscle cramps and spasms

muscle pain or stiffness

night blindness

no blood pressure or pulse

noisy breathing

overbright appearance of lights

pain in the joints

pale or blue lips, fingernails, or skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


skin rash

slurred speech

stopping of the heart

trouble in speaking

tunnel vision


Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of Overdose


decreased sexual ability

difficult urination

dry mouth

enlarged pupils

muscle weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at site



increased watering of the mouth



sore throat

trouble sleeping

unable to sleep


Incidence not known


constricted, pinpoint, or small pupils (black part of eye)


dry mouth

excess air or gas in the stomach or intestines

feeling of warmth

full feeling

increase in mucous from the lungs

increased need to urinate

increased sweating

passing gas

passing urine more often

redness of the face, neck, arms and occasionally, upper chest

redness of the skin

skin rash

stomach cramps

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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