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Mipomersen
Specialty Drug

Kynamro

MIPOMERSEN (mi" poe mer' sen) is used in combination with diet and other medicines to lower blood cholesterol levels in patients with a genetic disorder that results in high blood cholesterol levels. Compare ApoB inhibitors.
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Mipomersen Side Effects

What should I watch for?

This medicine can cause liver injury. The risk of liver injury is increased in patients who drink alcohol while taking this medicine. Do not drink more than one alcoholic drink per day while taking this medicine.

Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.

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Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Chills

cough

dark urine

diarrhea

fever

general feeling of discomfort or illness

headache

joint pain

light-colored stools

loss of appetite

muscle aches and pains

nausea and vomiting

runny nose

shivering

sore throat

sweating

trouble sleeping

unusual tiredness or weakness

upper right abdominal or stomach pain

vomiting

yellow eyes and skin

Less common

Arm, back, or jaw pain

bloating or swelling of the face, arms, hands, lower legs, or feet

chest pain or discomfort

chest tightness or heaviness

fast or irregular heartbeat

irregular, pounding, or racing heartbeat or pulse

rapid weight gain

shortness of breath

sweating

tingling of the hands or feet

unusual weight gain or loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

pain in the arms or legs

Less common

Abdominal or stomach pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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