Specialty Drug
LEUPROLIDE is a man-made protein that acts like a natural hormone in the body. It decreases testosterone in men and decreases estrogen in women. In men, this medicine is used to treat advanced prostate cancer. In women, some forms of this medicine may be used to treat endometriosis, uterine fibroids, or other female hormone-related problems. Compare gonadotropin releasing hormone agonists.

Lupron Depot-Ped Side Effects

What should I watch for?

Visit your doctor or health care professional for regular checks on your progress. During the first weeks of treatment, your symptoms may get worse, but then will improve as you continue your treatment. You may get hot flashes, increased bone pain, increased difficulty passing urine, or an aggravation of nerve symptoms. Discuss these effects with your doctor or health care professional, some of them may improve with continued use of this medicine.

Female patients may experience a menstrual cycle or spotting during the first months of therapy with this medicine. If this continues, contact your doctor or health care professional.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

For adults

Less common

Fast or irregular heartbeat


Bone, muscle, or joint pain


fast or irregular breathing

numbness or tingling of the hands or feet

puffiness or swelling of the eyelids or around the eyes

skin rash, hives, or itching

sudden, severe decrease in blood pressure and collapse

tightness in the chest

troubled breathing

For males only (adults)

More common

Arm, back, or jaw pain

bloody or cloudy urine

blurred vision

burning while urinating

chest pain or discomfort

chest tightness or heaviness

difficult or labored breathing

difficult, burning, or painful urination

difficulty with moving


frequent urge to urinate


increased urge to urinate during the night

muscle pain or stiffness



pain in the joints

pale skin

pounding in the ears

slow or fast heartbeat


troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

waking to urinate at night


Pain in the groin or legs (especially in the calves of the legs)

Incidence not known

Altered mental status

cardiovascular collapse

double vision

visual changes


For females only (adults)



deepening of voice

increased hair growth

mental depression

mood changes

For children


Body pain

burning, itching, redness, or swelling at the injection site

skin rash

For females only (children)—expected in first few weeks


Vaginal bleeding (continuing)

white vaginal discharge (continuing)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For adults

More common

Sudden sweating and feelings of warmth (also called hot flashes)

Less common

Bleeding, bruising, burning, itching, pain, redness, or swelling at the injection site

decreased interest in sexual intercourse

swelling of the feet or lower legs

swelling or increased tenderness of the breasts

trouble sleeping

weight gain

For females only (adults)

More common

Light, irregular vaginal bleeding

stopping of menstrual periods

Less common

Burning, dryness, or itching of the vagina

pelvic pain

For males only (adults)

More common

Back pain






general feeling of discomfort or illness

loss of appetite

pain or discomfort at the injection site

redness of the face, neck, arms, and occasionally, upper chest

runny nose


sore throat

sudden sweating

trouble sleeping

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Less common

Bone pain

decreased size of the testicles

inability to have or keep an erection

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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