Generic Fusilev

LEVOLEUCOVORIN is used to prevent or treat the harmful effects of some chemotherapy medicines like methotrexate. It is also used with 5-fluorouracil (5-FU) to treat colon cancer. Compare folate analogues.

What is Levoleucovorin?

Commonly Used Brand Name(s)Fusilev

Therapeutic ClassificationsMethotrexate Rescue




Levoleucovorin injection is used as an antidote to the harmful effects of methotrexate (a cancer medicine) that is given in high doses in patients with bone cancer (osteosarcoma). It is also used to treat overdosage of certain medicines. This medicine acts the same way in the body as folic acid (vitamin B9).

Levoleucovorin injection is also used in combination with 5-fluorouracil (Adrucil®) to relieve and prevent symptoms of patients with advanced metastatic (cancer that has already spread) cancer of the colon and rectum.

This medicine is to be given only by or under the direct supervision of a doctor.

Proper UseTOP

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins.

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of levoleucovorin injection in children younger than 6 years of age. Safety and efficacy have not been established.


Appropriate studies on the relationship of age to the effects of levoleucovorin injection have not been performed in geriatric patients with bone cancer. However, no geriatric-specific problems have been documented to date.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Fusilev® in elderly patients with advanced colorectal cancer.


Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast FeedingTOP

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical ProblemsTOP

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood problems (e.g., anemia caused by lack of vitamin B12)—Should not be used in patients with these conditions.


It is very important that your doctor check your closely to make sure that this medicine is working properly. Blood and urine tests will be needed to check for unwanted effects.

Do not take other medicines unless they have been discussed with your doctor. This includes 5-fluorouracil (Adrucil®) and combination of trimethoprim and sulfamethoxazole (Bactrim®, Septra®). Using any of these medicines together with levoleucovorin increases your risk of serious side effects. .

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