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Laronidase
Specialty Drug

Aldurazyme

LARONIDASE is a drug that is used to replace an enzyme that is missing in patients with some forms of mucopolysaccharidosis I (MPS I). It is used to treat some of the symptoms of the disease. This medicine is not a cure. Compare enzyme replacement therapies.
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Laronidase Side Effects

What should I watch for?

Your condition will be monitored carefully while you are receiving this medicine.

Visit your doctor for regular checks on your progress. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

There is a registry for MPS I patients to better understand the disease and the treatments. Talk to your doctor about signing up with the registry.

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Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Abdominal or stomach pain

accumulation of pus

back pain

black, tarry stools

bleeding gums

blood in urine or stools

blurred vision

chest pain

chest tightness

chills

clay-colored stools

confusion

dark urine

dizziness

drowsiness

facial swelling

faintness

fast, pounding, or irregular heartbeat or pulse

fever

flushing

headache

hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site

itching

lightheadedness when getting up from a lying or sitting position suddenly

loss of appetite

nausea or vomiting

pale skin

pinpoint red spots on skin

shortness of breath

skin rash

sweating

swollen, red, or tender area of infection

trouble breathing

unpleasant breath odor

unusual bleeding or bruising

unusual tiredness or weakness

vomiting of blood

yellow eyes or skin

Less common

Cough

difficulty breathing

itching skin

large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

noisy breathing

redness of skin

tightness in chest

wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bleeding, blistering, burning, coldness, or discoloration of skin

blindness

body aches or pain

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

decreased vision

diarrhea

difficulty in moving

ear congestion

feeling of pressure

loss of voice

muscle pain or stiffness

nasal congestion

overactive reflexes

pain in joints

runny nose

sneezing

sore throat

swelling of legs and feet

swelling or puffiness of face

varicose or spider veins

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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