Specialty Drug


IXABEPILONE is a chemotherapy drug. It is used to treat advanced breast cancer. Compare microtubule inhibitors.

Ixabepilone Side Effects

What should I watch for?

Your condition will be monitored carefully while you are receiving this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

This product may contain alcohol. Ask your pharmacist or healthcare provider if this medicine contains alcohol. Be sure to tell all healthcare providers you are taking this medicine. Certain medicines, like metronidazole and disulfiram, can cause an unpleasant reaction when taken with alcohol. The reaction includes flushing, headache, nausea, vomiting, sweating, and increased thirst. The reaction can last from 30 minutes to several hours.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools

body aches or pain

burning, numbness, tingling, or painful sensations

burning pain on urination

chest pain



difficult or labored breathing

ear congestion



loss of voice

lower back or side pain

nasal congestion

painful or difficult urination

pale skin

red, swelling, or painful skin

runny nose

scaling of the skin on the hands and feet

shortness of breath


sore throat

sores, ulcers, or white spots on the lips, tongue, or inside the mouth

swelling of the hands, ankles, feet, or lower legs

swollen glands

tightness in the chest

tingling of the hands and feet

troubled breathing with exertion

ulceration of the skin

unsteadiness or awkwardness

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight gain

weakness in the arms, hands, legs, or feet


Less common

Bleeding gums

blood in the urine or stools


decreased urination


dry mouth


fast heartbeat



increase in heart rate



joint pain, stiffness, or swelling


pinpoint red spots on the skin

rapid breathing


sunken eyes

swelling of the eyelids, face, or lips


trouble with swallowing

wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bad, unusual, or unpleasant (after) taste

bone pain

change in taste

cracked lips


difficulty having a bowel movement (stool)

discoloration of the fingernails or toenails

feeling of warmth

hair loss or thinning of the hair


lack or loss of strength

loss of appetite


redness of the face, neck, arms, and occasionally, upper chest

stomach pain

sudden sweating

swelling or inflammation of the mouth


weight loss

Less common

Darkening of the skin

flaking and falling off of the skin


trouble with sleeping

unable to sleep

watering of the eyes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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