IBUPROFEN LYSINE is a nonsteroidal anti-inflammatory drug (NSAID). It is used to close a heart defect called patent ductus arteriosus (PDA) in a baby who was born early. Compare NSAIDs.

Ibuprofen Lysine Side Effects

What should I watch for?

Your baby's condition will be watched closely while this treatment is given. Your baby will also receive regular blood tests and exams. Talk with your doctor or health care professional if you have any concerns.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Abdominal cramps

abdominal pain or swelling


black, tarry stools

bladder pain

blood in eyes

bloody or cloudy urine

blue lips, fingernails, or skin

bruising or purple areas on skin

bumps on skin

burning, itching, redness, or stinging of skin


cold sweats


cool, pale skin


coughing up blood

darkening of skin

decreased alertness

decreased frequency or amount of urine


difficulty in breathing

fast heartbeat


high blood pressure

increased blood pressure

increased hunger

increased thirst


irregular, fast or slow, or shallow breathing

irregular heartbeats


joint pain or swelling

loss of appetite

muscle cramps in hands, arms, feet, legs, or face

muscle twitching

nausea or vomiting



passing of gas

rapid, shallow breathing

rash on skin




shortness of breath


stomach pain, fullness, or discomfort

swelling of face, fingers, feet or lower legs


troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

Incidence not known

Bleeding, blistering, coldness, discoloration of skin, hives, infection, inflammation, itching, lumps, pain, rash, redness, scarring, soreness, swelling, tenderness, ulceration, or warmth at injection site

bleeding gums

blood in stools

chest pain or discomfort

clay-colored stools

dark urine

dilated neck veins

dry mouth

extreme fatigue

fast, pounding, or irregular heartbeat or pulse

flushed, dry skin

fruit-like breath odor

pinpoint red spots on skin

severe constipation

severe vomiting

stomach upset


swelling of abdominal or stomach area

tenderness in stomach area

ulcers, sores, or white spots in mouth

unexplained weight loss

unpleasant breath odor

vomiting of blood

weight gain


yellow eyes or skin

Symptoms of overdose


change in consciousness



loss of consciousness

rapid weight gain


swelling of face, ankles, or hands

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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