Insurance Coverage: Many major insurance plans no longer cover Duexis as of 2015. Learn More
What should I watch for?
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.
Do not take other medicines that contain aspirin, ibuprofen, or naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine.
This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. This can happen with no warning and may cause death. There is increased risk with taking this medicine for a long time. Smoking, drinking alcohol, older age, and poor health can also increase risks. Call your doctor right away if you have stomach pain or blood in your vomit or stool.
This medicine does not prevent heart attack or stroke. In fact, this medicine may increase the chance of a heart attack or stroke. The chance may increase with longer use of this medicine and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care professional.
This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
Interactions with Medications
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Abdominal or stomach pain, cramping, or burning
bloating or swelling of the face, arms, hands, lower legs, or feet
bloody or black, tarry stools
difficult, burning, or painful urination
frequent urge to urinate
general feeling of discomfort or illness
general feeling of tiredness or weakness
itching or rash
loss of appetite
lower back or side pain
muscle aches and pains
pounding in the ears
rapid weight gain
severe stomach pain
slow or fast heartbeat
stomach pain, continuing
tingling of the hands or feet
troubled breathing with exertion
unpleasant breath odor
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight gain or loss
vomiting of blood or material that looks like coffee grounds
yellow eyes or skin
Incidence not known
Blistering, peeling, or loosening of the skin
change in consciousness
confusion as to time, place, or person
cracks in the skin
darkening of the skin
holding false beliefs that cannot be changed by fact
loss of consciousness
loss of heat from the body
pain in lower back or side
pains in the chest, groin, or legs, especially calves of the legs
red skin lesions, often with a purple center
red, irritated eyes
red, swollen skin
severe headaches of sudden onset
sores, ulcers, or white spots in the mouth or on the lips
stiff neck or back
sudden loss of coordination
sudden onset of shortness of breath for no apparent reason
sudden onset of slurred speech
sudden vision changes
troubled breathing with exertion
unusual excitement, nervousness, or restlessness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.