Glycerol Phenylbutyrate
Specialty Drug


GLYCEROL PHENYLBUTYRATE (gli ser ol fen il bue ti rate) is used to manage the amount of ammonia in the blood of patients with urea cycle disorders. This medicine is not a cure. Compare enzyme replacement therapies.

What is Glycerol Phenylbutyrate?



What should I tell my doctor?TOP

They need to know if you have any of these conditions:

  • intestine problems
  • kidney disease
  • liver disease
  • pancreatic disease
  • an unusual or allergic reaction to glycerol phenylbutyrate, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this drug?TOP

Take this medicine by mouth. Follow the directions on the prescription label. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take this medicine with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

This medicine is used in combination with a low protein diet. Some patients may also need to take dietary supplements.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 2 years for selected conditions, precautions do apply.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

What if I miss a dose?TOP

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I store this drug?TOP

Keep out of the reach of children.

Store between 68 and 77 degrees F (20 and 25 degrees C). Throw away any unused medicine after the expiration date.

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