SODIUM HYALURONATE is used to treat pain in the knee due to osteoarthritis. It can also be used during eye surgery. Compare Viscosupplements.

Insurance Coverage. Many major insurance plans no longer cover Euflexxa as of 2015. Learn More


What is Euflexxa?

SODIUM HYALURONATE is used to treat pain in the knee due to osteoarthritis. It can also be used during eye surgery.

Commonly Used Brand Name(s)Euflexxa, Gel-One, Hyalgan, Hyalgan L/L, Supartz, Supartz FX

Therapeutic ClassificationsCartilaginous Defect Repair Agent


Hyaluronate is similar to a substance that occurs naturally in joints and that helps joints work properly by acting like a lubricant and shock absorber. This medicine is injected directly into the knee to relieve pain caused by osteoarthritis.

This medicine is to be administered only by or under the immediate supervision of your doctor.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For parenteral dosage form (injection):
    • For knee pain caused by osteoarthritis:
      • Adults—By injection into the knee, 20 milligrams (mg) once a week (one week apart) for a total of five injections.
      • Children—Use and dose must be determined by your doctor.

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of hyaluronate in children with use in other age groups.


Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of hyaluronate in the elderly with the use in other age groups.

Breast FeedingTOP

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical ProblemsTOP

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Skin infection or other problems at the place where the injection is to be given—This medicine should not be injected there.


For the first 48 hours after you receive this medicine, avoid strenuous activities or prolonged (more than 1 hour) activities that put a lot of weight on your legs, such as jogging, heavy lifting, playing tennis, or standing on your feet for a long period of time.

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