EPIRUBICIN is a chemotherapy drug. This medicine is used to treat breast cancer. Compare anthracyclines.

Ellence Side Effects

What should I watch for?

Your condition will be monitored carefully while you are receiving this medicine. You will need important blood work done while you are taking this medicine.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Your urine may turn red for a few days after your dose. This is not blood. If your urine is dark or brown, call your doctor.

In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Men and women of childbearing age should use effective birth control methods while using taking this medicine. Do not become pregnant while taking this medicine. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

There is a maximum amount of this medicine you should receive throughout your life. The amount depends on the medical condition being treated and your overall health. Your doctor will watch how much of this medicine you receive in your lifetime. Tell your doctor if you have taken this medicine before.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools

bleeding, redness, or ulcers in the mouth or throat

chest pain

cough or hoarseness

fever or chills

lower back or side pain

pain or burning in the mouth or throat

painful or difficult urination

shortness of breath

sore throat

sores, ulcers, or white spots in the mouth or on the lips

swollen glands

unusual bleeding or bruising

unusual tiredness or weakness

Less common

Blood in the urine or stools

pinpoint red spots on the skin

red streaks along the injected vein


Darkening or redness of the skin at place of irradiation

difficulty with breathing

fast or irregular heartbeat

joint pain

pain, redness, or warmth at the injection site

skin rash or itching

swelling of the abdomen or stomach, lower legs, and feet

swelling or tenderness of the lymph nodes, abdomen, side or lower back


Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Abdominal or stomach swelling or tenderness

high fever

stomach pain

swelling of the lining of the mouth, nose, or throat


Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Absent, missed, or irregular menstrual periods

burning, dry, or itching eyes


discharge or excessive tearing

feeling of warmth

hair loss or thinning of the hair


redness of the face, neck, arms, and occasionally, upper chest

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

stopping of menstrual bleeding

sudden sweating

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Less common

Changes in the skin

loss of appetite

weight loss


Darkening of the soles, palms, or nails

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

Fast or irregular heartbeat

shortness of breath

swelling of the abdomen or stomach, feet, and lower legs

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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