The GoodRx Top 10 (2016)

Several times a year, GoodRx creates a list of the most expensive prescriptions in the U.S. To form our list, we use actual prices from a sample of claims as reported by pharmacies across the country. We also display the GoodRx Fair Price for a 30-day supply of the most commonly prescribed form, dosage and quantity.

Rank Drug GoodRx Fair Price
1
Yellow Oblong Gsi And 7977 - Sovaldi 400mg Tablet
Sovaldi (sofosbuvir)
81,000 See Prices
Sovaldi (sofosbuvir) is a hepatitis C virus polymerase inhibitor, available as a once-daily tablet. For patients with chronic genotype 1 hepatitis C infection, initiating therapy with simeprevir (Olysio) plus sofosbuvir (Sovaldi) for 12 weeks is the preferred regimen resulting in cure rates greater than 90 percent. Sovaldi is expensive in the United States, partly because the combination regimen of simeprevir plus sofosbuvir is not specifically approved by the Food and Drug Administration, so insurers may be reluctant to pay for it.
2
Harvoni (ledipasvir and sofosbuvir)
79,200 See Prices
Harvoni (ledipasvir and sofosbuvir) is another effective and well tolerated interferon-free option used for chronic genotype 1 hepatitis C infection. Harvoni results in sustained virologic response (SVR) rates, and thus effective cure, in over 90 percent of people with genotype 1 hepatitis C. How long you take Harvoni and whether you take it with ribavirin depend on your treatment history and whether or not you have liver cirrhosis. Cost and insurance coverage are an issue with Harvoni but its favorable side effect profile, minimal drug interactions, and its ease of administration (a single pill once daily) make it an attractive choice.
3
Cinryze (human c1 esterase inhibitor)
Drug Class: C1 Inhibitors
72,100 See Prices
Cinryze (C1 esterase inhibitor) is a medication used for hereditary angioedema (HAE). HAE is a rare disorder that leads to acute episodes of swelling in the throat often with airway compromise. Cinryze is what is called a C1 inhibitor medication and it is pooled from human plasma. Cinryze is the best studied first-line therapy for acute episodes of angioedema (swelling in mouth and throat) in patients with HAE.
4
Daklinza (daclatasvir)
Drug Class: NS5A Inhibitors
54,300 See Prices
Daklinza (Daclatasvir) is a newer hepatitis C medication that works by binding to a protein in the hepatitis C virus, which helps keep the virus from replicating. Daklinza specifically treats genotype 3 hepatitis C infections, which have historically been the most difficult to cure. Daklinza plus Sovaldi for 12 weeks is now the preferred regimen for patients with genotype 3. These two medications together result in a cure in 98 percent of patients.
5
yellow - H.P Acthar Gel 80unit/ml Repository Injection
HP Acthar (corticotropin)
51,600 See Prices
HP Acthar (corticotropin) is an injection that stimulates the adrenal cortex to secrete adrenal steroids (including cortisol) and aldosterone, working as a potent anti-inflammatory. It is used for acute exacerbations of multiple sclerosis (MS) and gout, among other conditions. HP Acthar is a purified form of bovine (cow) or porcine (pig) adrenocorticotropic hormone (ACTH) and is an expensive alternative to glucocorticoids like Solu-medrol. It can be used in patients with MS who cannot tolerate high-dose glucocorticoids or prefer self-injection (instead of intravenous infusion).
6
White Tmc435 150 - Olysio 150mg Capsule
Olysio (simeprevir)
44,800 See Prices
Olysio (simeprevir) is a protease inhibitor used for hepatitis C, available as a capsule taken once daily. For patients with chronic genotype 1 hepatitis C infection, initiating therapy with simeprevir (Olysio) plus sofosbuvir (Sovaldi) for 12 weeks is the preferred regimen resulting in cure rates greater than 90 percent. It is expensive in the United States, partly because the combination regimen of simeprevir plus sofosbuvir is not specifically approved by the Food and Drug Administration, so insurers may be reluctant to pay for it.
7
Orkambi (lumacaftor and ivacaftor)
Drug Class: CFTR Potentiators
44,200 See Prices
Orkambi is a drug used to treat cystic fibrosis (CF). Orkambi is a combination of two medications (lumacaftor and ivacaftor), and is used only in CF patients with a specific genetic mutation (F508del). When used in CF patients with this mutation, Orkambi yields modest improvements in lung function and reduces episodes of deteriorating lung function. In studies, patients taking Orkambi had significant improvements in measured lung function, and improvement in weight and quality of life. The main side effects reported are chest discomfort and shortness of breath, particularly in patients with worse baseline lung function, so monitoring is recommended when Orkambi is first prescribed.
8
White Msd 602 Cuprimine - Cuprimine 250mg Capsule
Cuprimine (penicillamine)
Drug Class: Antirheumatics
39,800 See Prices
Cuprimine (D-penicillamine), firmly attaches (chelates) to lead, copper, mercury and other heavy metals, which then allows your body to clear them through the urine. Cuprimine is used in the treatment of several different diseases: Wilson’s disease (an accumulation of copper in the liver), and lead and mercury poisoning. It has also been used in the treatment of rheumatoid arthritis. Cuprimine is another example of an extreme price increase on an existing drug - the cost rose by more than 400% in 2015.
9
Firazyr (icatibant)
35,800 See Prices
Firazyr (icatibant) is used for hereditary angioedema (HAE) in people over 18 years of age. HAE is a rare disorder that leads to acute episodes of swelling in the throat often with airway compromise. Infusions under the skin at 30 mg per dose are given to patients with compromised breathing. Firazyr works by inhibiting bradykinin from binding to the receptor and treats the symptoms associated with acute attacks. It is one of the first line treatments of HAE attacks in adults.
10
Beige Oval Av2 - Viekira Pak
Viekira Pak (ombitasvir, paritaprevir, ritonavir, and dasabuvir)
34,600 See Prices
Viekira Pak (ombitasvir/paritaprevir/ritonavir and dasabuvir) combines three hepatitis C virus antiviral agents with different mechanisms of action into one pill. Viekira Pak is ombitasvir/paritaprevir/ritonavir in one pill and dasabuvir in another pill. This newer interferon-free regimen is used with or without ribavirin in patients with genotype 1a or 1b infection. Viekira Pak comes in a convenient punch out kit where you take 2 tablets of the mixture of ombitasvir/paritaprevir/ritonavir and 1 tablet of dasabuvir twice a day for 12 or 24 weeks depending on your genotype. It is highly effective in treatment-naïve hepatitis C patients and in those who have failed prior treatment with peginterferon and ribavirin, even in the setting of cirrhosis. Viekira Pak results in a sustained viral response (cure) in greater than 95% of patients with hep C.

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