The GoodRx Top 10 (2016)

Several times a year, GoodRx creates a list of the most-dispensed prescriptions in the U.S. To form our list, we look at a sample of claims as reported by pharmacies across the country. We combine prescriptions for brands and generics; we also display the GoodRx Fair Price for the most common form, dosage and quantity.

Rank Drug GoodRx Fair Price
White Oblong M365 - Hydrocodone Bitartrate/Acetaminophen 5mg-325mg Tablet
Vicodin, Norco, Xodol (hydrocodone/acetaminophen)
14 See Prices
The combination of hydrocodone and acetaminophen (Vicodin, Norco, Xodol, Lorcet, Lortab) is used to treat moderate to severe pain, from a variety of causes. Hydrocodone is an opiate and is considered a narcotic pain medicine, while acetaminophen (Tylenol) is also sold over the counter for pain. Other opioid and acetaminophen combinations are available, but hydrocodone and acetaminophen is the most popular. This may change now that the FDA has reclassified hydrocodone and acetaminophen as a schedule 2 controlled substance with more restrictions.
White Oblong L 5 And M - Levothyroxine Sodium 50mcg Tablet
Synthroid, Levoxyl, Unithroid (levothyroxine)
Drug Class: Thyroxines
12 See Prices
Levothyroxine (Synthroid, Unithroid, Levoxyl, Levothroid) is a synthetically prepared thyroid hormone that can improve symptoms of thyroid deficiency. There are several brand and generic levothyroxine choices available; however, they aren't interchangeable. Generic levothyroxine is very inexpensive, though most of the brands available are also affordable.
Peach Round 5443 And Dan Dan - Prednisone 20mg Tablet
Delasone, Sterapred (prednisone)
Drug Class: Corticosteroids
5 See Prices
Prednisone (Sterapred, Deltasone) is a synthetic corticosteroid used to treat a very wide variety of conditions, and is effective as an immunosuppressant. Corticosteroids can have some major side effects, but they are one of the oldest and most effective treatments for several conditions, and prednisone was one of the first introduced.
Pink Round Lupin And 20 - Lisinopril 20mg Tablet
Prinivil, Zestril (lisinopril)
Drug Class: ACE Inhibitors
7 See Prices
Lisinopril (Prinivil, Zestril) is an ACE inhibitor used to treat high blood pressure, and in combination with other medications to treat heart failure. Lisinopril was the third ACE inhibitor to become available. It may be more convenient than some of the other options because it is longer-acting, meaning you only need to take one tablet per day rather than two or three.
Yellow Amox 500 Gg 849 - Amoxicillin 500mg Capsule
Amoxil (amoxicillin)
9 See Prices
Amoxicillin (Amoxil) is a penicillin antibiotic used to treat many different types of bacterial infections. It is one of the most commonly prescribed antibiotics for children, and is offered for free or at a reduced cost under many pharmacies' discount generic programs.
Yellow D 03 - Gabapentin 300mg Capsule
Neurontin (gabapentin)
Drug Class: Anti-epileptics
11 See Prices
Gabapentin (Neurontin) is an anti-epileptic drug also approved to relieve some types of nerve pain, including pain from shingles (postherpetic neuralgia).
White Round 234 And M - Metformin Hydrochloride 500mg Tablet
Glucophage (metformin)
Drug Class: Biguanides
5 See Prices
Metformin (Glucophage) is a biguanide used in combination with diet and exercise to help control blood sugar levels in type 2 diabetes. It is a first-line drug, meaning it is often tried before other treatment options, and it may be used alone or with other medications. Metformin is believed to be the most widely prescribed diabetes medication in the world and it is available as a very inexpensive generic in the US. Many pharmacies offer it for free or at a reduced cost under their discount generic programs.
White Oval Apo And Atv 20 - Atorvastatin Calcium 20mg Tablet
Lipitor (atorvastatin)
Drug Class: Statins
12 See Prices
Atorvastatin (Lipitor) is a statin used to treat high cholesterol. Prior to its release as generic atorvastatin in 2011, it was considered the top drug by sales for most of the previous decade. It is still one of the most commonly prescribed statins, and though not as inexpensive as simvastatin (Zocor), the generic price has continued to drop.
Peach Oval 2088 V - Alprazolam 0.5mg Tablet
Xanax, Niravam (alprazolam)
Drug Class: Benzodiazepines
8 See Prices
Alprazolam (Xanax, Niravam) is a benzodiazepine used to relieve anxiety and panic attacks. It works quickly to relieve symptoms, but carries a risk for dependence and abuse. Some controversy exists around the potential for misuse: there is evidence that those taking alprazolam for medical reasons are relatively unlikely to abuse it compared to the high number of prescriptions, however, it is often used recreationally.
White Octagon H12 And Lu - Amlodipine Besylate 5mg Tablet
Norvasc (amlodipine)
7 See Prices
Amlodipine (Norvasc) is a calcium channel blocker (CCB) used to treat high blood pressure and chest pain (angina). It is one of the most common heart meds, and is on the WHO list of essential medicines for basic health care. It became available as generic amlodipine in 2007, and is one of the most inexpensive generics in the US - even available for free at some pharmacies.

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GoodRx is not sponsored by or affiliated with any of the pharmacies identified in its price comparisons. All trademarks, brands, logos and copyright images are property of their respective owners and rights holders and are used solely to represent the products of these rights holders. This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. GoodRx is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information on the site. GoodRx provides no warranty for any of the pricing data or other information. Please seek medical advice before starting, changing or terminating any medical treatment.