LIPOSOMAL DOXORUBICIN is a chemotherapy drug. This medicine is used to treat many kinds of cancer like Kaposi's sarcoma, multiple myeloma, and ovarian cancer. Compare anthracyclines.

Doxil Side Effects

What should I watch for?

Your condition will be monitored carefully while you are receiving this medicine. You will need important blood work done while you are taking this medicine.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Your urine may turn orange-red for a few days after your dose. This is not blood. If your urine is dark or brown, call your doctor.

In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.

Call your doctor or health care professional for advice if you get a fever (100.5 degrees F or higher), chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Men and women of childbearing age should use effective birth control methods while using taking this medicine. Do not become pregnant while taking this medicine. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools

blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet

blood in the urine or stools


cough or hoarseness

facial swelling



loss of strength and energy

lower back or side pain

numbness, pain, tingling, or unusual sensations in the palms of the hands or bottoms of the feet

painful or difficult urination

pinpoint red spots on the skin

shortness of breath

sore throat

sores in the mouth and on the lips

unusual bleeding or bruising

unusual tiredness or weakness

Less common

Pain at the injection site

skin rash or itching


Chest pain

decreased urine output

dilated neck veins

extreme fatigue

irregular breathing

irregular heartbeat

swelling of the face, fingers, feet, or lower legs

tightness in the chest

weight gain

yellowing of the eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Creamy white, curd-like patches in mouth or throat


loss of appetite


pain when eating or swallowing

sore throat

swallowing problems


Less common


back pain

bad, unusual, or unpleasant aftertaste

burning, dry, or itching eyes

change in skin color



excessive tearing


joint pain

muscle aches

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

trouble sleeping


Abnormal thinking

change in sense of smell


clumsiness, unsteadiness, trembling, or problems with muscle coordination



general feeling of discomfort or illness



Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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