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Dalfampridine
Specialty Drug

Ampyra

DALFAMPRIDINE may help improve walking in patients with multiple sclerosis. This medicine is not a cure. Compare potassium channel blockers.
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What is Dalfampridine?

Commonly Used Brand Name(s)Ampyra

Therapeutic ClassificationsCentral Nervous System Agent

Pharmacologic ClassificationsPotassium Channel Blocker

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OverviewTOP

Dalfampridine is used to help improve walking in patients with multiple sclerosis. This medicine is a potassium channel blocker.

This medicine is available only with your doctor's prescription.

Proper UseTOP

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Do not change your dose without checking first with your doctor.

This medicine should come with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Swallow the extended release tablet whole. Do not crush, break, chew, or dissolve it.

You may take this medicine with or without food.

DosingTOP

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (extended release tablets):
    • For walking impairment:
      • Adults—10 milligrams (mg) two times a day (taken at least 12 hours apart). Do not take more than two tablets in a 24-hour period.
      • Children—Use and dose must be determined by your doctor.

Missed DoseTOP

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Use & StorageTOP

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

AllergiesTOP

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

PediatricTOP

Appropriate studies have not been performed on the relationship of age to the effects of dalfampridine in the pediatric population. Safety and efficacy have not been established.

GeriatricTOP

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dalfampridine in the elderly. However, elderly patients are more likely to have seizures and age-related kidney problems, which may require caution in patients receiving dalfampridine.

PregnancyTOP

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast FeedingTOP

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical ProblemsTOP

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Kidney disease, moderate to severe or
  • Seizures, history of—Should not be used in patients with these conditions.

PrecautionsTOP

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

Dalfampridine may cause seizures. Stop using this medicine and check with your doctor right away if you have convulsions or seizures while taking this medicine.

Do not take dalfampridine together with other aminopyridine medicines (e.g., compounded 4-AP, fampridine). Taking these medicines together will increase chance for more serious side effects.

This medicine may cause serious type of allergic reactions, including anaphylaxis. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face, large, hive-like swelling on face, eyelids, lips, tongue and/or throat, If these side effects occur, get emergency help at once.

Urinary tract infections may occur while using this medicine. Check with your doctor right away if you have the following symptoms while using this medicine: bladder pain, bloody or cloudy urine, difficult, burning, or painful urination, frequent urge to urinate, or lower back or side pain.

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