CARFILZOMIB targets a specific protein within cancer cells and stops the cancer cells from growing. It is used to treat multiple myeloma. Compare proteasome inhibitors.

Carfilzomib Side Effects

What should I watch for?

Your condition will be monitored carefully while you are receiving this medicine. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

You may need blood work done while you are taking this medicine.

Do not become pregnant while taking this medicine or for at least 30 days after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Men should not father a child while taking this medicine and for 90 days after stopping it. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.

You may get dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common


black, tarry stools

bleeding gums

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the urine or stools

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain



cough or hoarseness

decreased urine output


difficult or labored breathing

difficulty with moving



fast or irregular heartbeat



irregular heartbeat



lower back or side pain

muscle spasms (tetany) or twitching

nausea or vomiting

numbness or tingling in the hands, feet, or lips

painful or difficult urination

pale skin

pinpoint red spots on the skin

pounding in the ears

rapid weight gain


slow or fast heartbeat


tightness in the chest

tingling of the hands or feet


troubled breathing with exertion

ulcers, sores, or white spots in the mouth

unsteadiness or awkwardness

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight gain or loss

Less common



muscle pain or cramps

painful blisters on the trunk of the body

weakness in the arms, hands, legs, or feet


Dark-colored urine

general feeling of discomfort or illness

general feeling of tiredness or weakness

light-colored stools

stomach pain, continuing

thickening of bronchial secretions

yellow eyes or skin

Incidence not known


dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


joint pain, stiffness, or swelling


stomach pain


Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain

body aches or pain

bone pain



dry mouth

ear congestion

flushed, dry skin

fruit-like breath odor

increased hunger

increased thirst

increased urination

loss of appetite

loss of voice

metallic taste

muscle weakness

pain in the arms or legs

runny nose


sore throat

trouble sleeping

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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