Buprenex Side Effects

What should I watch for?

Tell your doctor or health care professional if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may develop tolerance to the medicine. Tolerance means that you will need a higher dose of the medicine for pain relief. Tolerance is normal and is expected if you take this medicine for a long time.

Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a non-medical reason. If you have pain, you have a medical reason to take pain medicine. Your doctor will tell you how much medicine to take. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

If you are also taking a narcotic medicine for pain or cough or another medicine that also causes drowsiness, you may have more side effects. Give your health care provider a list of all medicines you use. Your doctor will tell you how much medicine to take. Do not take more medicine than directed. Call emergency for help if you have problems breathing or unusual sleepiness.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine will cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common


relaxed and calm



Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the site

bluish color of the fingernails, lips, skin, palms, or nail beds

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or discomfort


difficult or labored breathing

feeling, seeing, or hearing things that are not there

feeling that others are watching you or controlling your behavior

feeling that others can hear your thoughts


severe mood or mental changes

shortness of breath

slurred speech

tightness of the chest

unusual behavior


Incidence not known




difficulty breathing

dry mouth


irregular heartbeats


large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

loss of muscle coordination


noisy breathing




trouble sleeping


Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common


Less common

Constricted, pinpoint, or small pupils (black part of the eye)

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

extremely shallow or slow breathing




Burning, dry, or itching eyes


continuing ringing or buzzing or other unexplained noise in the ears

decrease in frequency of urination

decrease in urine volume


difficulty in passing urine (dribbling)

discharge, excessive tearing


dry mouth

false or unusual sense of well-being

fast, pounding, or irregular heartbeat or pulse

feeling of warmth

hearing loss

itching of the skin

painful urination

pounding in the ears

redness of the face, neck, arms and occasionally, upper chest

redness, pain, or swelling of the eye, eyelid, or inner lining of eyelid

unusual tiredness or weakness

Incidence not known

Acid or sour stomach



bluish lips or skin

change in vision

excess air or gas in the stomach or intestines

feeling of unreality

full feeling

general feeling of discomfort or illness


hives or welts

impaired vision


loss of appetite

not breathing

paleness of the skin

passing gas

redness of the skin

sense of detachment from self or body

skin rash

stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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