Brentuximab Vedotin


BRENTUXIMAB VEDOTIN is a monoclonal antibody and a chemotherapy drug. It is used for treating Hodgkin lymphoma and certain non-Hodgkin lymphomas, such as systemic anaplastic large cell lymphoma. Compare microtubule inhibitors.

Brentuximab Vedotin Side Effects

What should I watch for?

Visit your doctor for checks on your progress. This drug may make you feel generally unwell. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

In some patients, this medicine may cause a serious brain infection that may cause death. If you have any problems seeing, thinking, speaking, walking, or standing, tell your doctor right away. If you cannot reach your doctor, urgently seek other source of medical care.

Do not become pregnant while taking this medicine or for 6 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 6 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

This may interfere with the ability to father a child. You should talk to your doctor or health care professional if you are concerned about your fertility.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools

bleeding gums

blood in the urine or stools

body aches or pain

burning, numbness, tingling, or painful sensations



difficult or labored breathing

difficulty with breathing

ear congestion



loss of voice

lower back or side pain


painful or difficult urination

pale skin

pinpoint red spots on the skin


sore throat

stuffy or runny nose

swollen, painful, or tender lymph glands in the neck, armpit, or groin

tightness in the chest

troubled breathing with exertion

ulcers, sores, or white spots in the mouth

unsteadiness or awkwardness

unusual bleeding or bruising

unusual tiredness or weakness

weakness in the arms, hands, legs, or feet

Less common


back pain

bladder pain

blistering, peeling, or loosening of the skin

bloating or swelling of the face, arms, hands, lower legs, or feet

blurred vision

chest pain

cloudy urine




dizziness or lightheadedness



fast heartbeat

frequent urge to urinate

general feeling of discomfort or illness

irregular heartbeat


joint pain, stiffness, or swelling

muscle pain

rapid weight gain

red skin lesions, often with a purple center

red, irritated eyes

severe pain in the chest

stomach pain

sudden onset of severe breathing difficulty

sudden shortness of breath or troubled breathing

thickening of bronchial secretions

unusual weight gain or loss

Incidence not known

Bloody stools




severe abdominal pain, cramping, or burning

severe constipation

severe vomiting

vomiting of material that looks like coffee grounds

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Decreased appetite or weight

difficulty having a bowel movement (stool)

difficulty with moving

hair loss or thinning of the hair

muscle spasms

muscle stiffness

night sweats

pain in the arms or legs


trouble sleeping


Less common

Dry skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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