Specialty Drug


BOSENTAN is used to treat a serious heart and lung disorder called primary pulmonary hypertension. This medicine may help to increase your ability to exercise and improve your breathing. Compare endothelin antagonists.

Bosentan Side Effects

What should I watch for?

Visit your doctor or health care professional for checks on your progress. Despite receiving this medicine, your condition may worsen and you may need your dose adjusted. Call your doctor or health care professional if your conditions gets worse.

Pregnancy must be avoided while taking this medicine due to the potential for serious side effects to an unborn child. If you are female of child-bearing potential, you will have to have pregnancy tests regularly (at least monthly) while you are taking this medicine. Discuss options to prevent pregnancy with your physician. This medicine may reduce the effectiveness of hormonal birth control methods, including birth control pills, patches, implanted hormonal products, or injections.

This medicine has caused reduced sperm counts in some men. This may interfere with the ability to father a child. You should talk to your doctor or health care professional if you are concerned about your fertility.

Your health care professional will have to check blood tests regularly (at least monthly) to check the effect of this medicine on your liver.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Blurred vision



dark urine

faintness or lightheadedness when getting up from a lying or sitting position

fever with or without chills

light-colored stools

loss of appetite

nausea and vomiting

stomach pain

sudden sweating

unusual tiredness or weakness

yellow eyes or skin

Less common


Incidence not known

Black, tarry stools

bleeding gums

blood in the urine or stools

blue lips and fingernails

chest pain


clay-colored stools

coughing that sometimes produces a pink frothy sputum

coughing up blood

dark urine

decrease in the amount of urine

difficult, fast, or noisy breathing, sometimes with wheezing


fast heartbeat

fatigue on exertion





increased sweating



joint pain, stiffness, or swelling

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

noisy, rattling breathing

pale skin

pinpoint red spots on the skin


redness of the skin

shortness of breath

swelling of the eyelids, face, lips, hands, fingers, legs, ankles, or feet

tightness in the chest

troubled breathing at rest

troubled breathing or swallowing

troubled breathing with exertion

unpleasant breath odor

unusual bleeding or bruising

vomiting of blood

weight gain


Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Increased heart rate

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Fast, irregular, pounding, or racing heartbeat or pulse

feeling of warmth

muscle aches

redness of the face, neck, arms, and occasionally upper chest

sore throat

stuffy or runny nose

Less common

Acid or sour stomach




stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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