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Apomorphine
Specialty Drug

Apokyn

APOMORPHINE is used to treat 'off' episodes in advanced Parkinson's disease. These episodes affect your ability to move or perform tasks. Compare dopamine agonists.
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Apomorphine Side Effects

What should I watch for?

Visit your doctor or health care professional for regular checks on your progress.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. You may experience flushing, nausea, vomiting, pale skin, or sweating before dizziness or fainting occurs. Do not get up too quickly from a lying or sitting position. Report any dizziness or related symptoms to your health care provider as soon as possible. Alcohol may increase dizziness and drowsiness. Avoid alcoholic drinks. Do not take any medications that cause drowsiness without first checking with your health care provider.

If you find that you have sudden feelings of wanting to sleep during normal activities, like cooking, watching television, or while driving or riding in a car, you should contact your health care professional.

This medicine may cause severe nausea and vomiting. Your doctor may prescribe a medication to prevent these symptoms. Do not treat yourself. Not all medicines for nausea and vomiting can be used with this medicine. Talk to your doctor about which one may be right for you.

There have been reports of increased sexual urges or other strong urges such as gambling while taking some medicines for Parkinson's disease. If you experience any of these urges while taking this medicine, you should report it to your health care provider as soon as possible.

You should check your skin often for changes to moles and new growths while taking this medicine. Call your doctor if you notice any of these changes.

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Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Chest pain, discomfort, or pressure

chills

cold sweats

confusion

dizziness, faintness, or light-headedness when getting up from lying or sitting position

falling asleep during activity

mood or mental changes

seeing, hearing, or feeling things that are not there

swelling

twitching, twisting, uncontrolled repetitive movements of tongue, lips, face, arms, or legs

Less common

Arm, back, neck or jaw pain or discomfort

chest tightness or heaviness

fainting

fast or irregular heartbeat

low blood pressure or pulse

nausea

shortness of breath

sweating

unconsciousness

vomiting

Rare

Irregular heartbeat

recurrent fainting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site

blurred vision

dizziness

drowsiness

runny nose

sleepiness

yawning

Rare

Painful or prolonged erection of the penis

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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