amitriptyline (Amitid, Amitril, Elavil, Endep)

Tricyclic Antidepressants

AMITRIPTYLINE is used to treat depression.

Side effects of amitriptyline

Tell your doctor if your symptoms do not get better or if they get worse. Visit your doctor or health care professional for regular checks on your progress. Because it may take several weeks to see the full effects of this medicine, it is important to continue your treatment as prescribed by your doctor.

Patients and their families should watch out for new or worsening thoughts of suicide or depression. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Do not treat yourself for coughs, colds, or allergies without asking your doctor or health care professional for advice. Some ingredients can increase possible side effects.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water will help. Contact your doctor if the problem does not go away or is severe.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.

This medicine can cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach pain

agitation

black, tarry stools

bleeding gums

blood in urine or stools

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

change in consciousness

changes in patterns and rhythms of speech

chest pain or discomfort

chills

cold sweats

coma

confusion

confusion about identity, place, and time

continuing ringing, buzzing, or other unexplained noise in ears

convulsions

cool, pale skin

cough or hoarseness

dark urine

decrease in frequency of urination

decrease in urine volume

decreased urine output

difficulty in breathing

difficulty in passing urine (dribbling)

difficulty in speaking

disturbance of accommodation

disturbed concentration

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

double vision

drooling

dry mouth

excitement

fainting

false beliefs that cannot be changed by facts

fast, slow, or irregular heartbeat

fear or nervousness

fever with or without chills

flushed, dry skin

fruit-like breath odor

general feeling of tiredness or weakness

headache

hearing loss

high fever

high or low blood pressure

hostility

inability to move arms, legs, or facial muscles

inability to speak

increased hunger

increased need to urinate

increased ocular pressure

increased sweating

increased thirst

increased urination

irritability

lack of coordination

lethargy

light-colored stools

lip smacking or puckering

loss of appetite

loss of balance control

loss of bladder control

loss of consciousness

lower back or side pain

mental depression or anxiety

muscle spasm or jerking of all extremities

muscle tightness

muscle trembling, jerking, or stiffness

muscle twitching

nausea and vomiting

nightmares or unusually vivid dreams

overactive reflexes

painful or difficult urination

passing urine more often

pinpoint red spots on skin

poor coordination

pounding in the ears

puffing of cheeks

rapid or worm-like movements of tongue

rapid weight gain

restlessness

seeing, hearing, or feeling things that are not there

seizures

severe muscle stiffness

shakiness and unsteady walk

shivering

shortness of breath

shuffling walk

sleeplessness

slow speech

slurred speech

sore throat

sores, ulcers, or white spots on lips or in mouth

stiffness of limbs

stupor

sudden loss of consciousness

sweating

swelling of face, ankles, or hands

swelling or puffiness of face

swollen glands

talking or acting with excitement you cannot control

trouble in speaking

trouble sleeping

troubled breathing

twisting movements of body pain or discomfort in arms, jaw, back, or neck

unable to sleep

uncontrolled chewing movements

uncontrolled movements, especially of arms, face, neck, back, and legs

unexplained weight loss

unpleasant breath odor

unsteadiness, trembling, or other problems with muscle control or coordination

unusual bleeding or bruising

unusual tiredness or weakness

unusually pale skin

upper right abdominal pain

vomiting of blood

weakness in arms, hands, legs, or feet

weight gain or loss

yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of Overdose

Clumsiness

drowsiness

low body temperature

muscle aches

muscle weakness

sleepiness

tiredness

weak or feeble pulse

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Bigger, dilated, or enlarged pupils (black part of eye)

black tongue

bloating

breast enlargement in females

constipation

decreased interest in sexual intercourse

diarrhea

hair loss, thinning of hair

hives or welts

inability to have or keep an erection

increased in sexual ability, desire, drive, or performance

increased interest in sexual intercourse

increased sensitivity of eyes to light

loss in sexual ability, desire, drive, or performance

loss of sense of taste

redness or other discoloration of skin

severe sunburn

skin rash

swelling of testicles

swelling of the breasts or breast soreness in males

swelling of the parotid glands

swelling or inflammation of the mouth

unexpected or excess milk flow from breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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