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Alitretinoin
Specialty Drug

Panretin

Alitretinoin (Panretin) is an expensive drug used on the skin to treat Kaposi's sarcoma lesions. This drug is less popular than comparable drugs. There are currently no generic alternatives to Panretin. It is covered by most Medicare and insurance plans, but pharmacy coupons or cash prices may be lower. Compare retinoids.
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What is Alitretinoin?

Commonly Used Brand Name(s)Panretin

Therapeutic ClassificationsDermatological Agent

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OverviewTOP

Alitretinoin is used as a topical treatment for cutaneous AIDS-related Kaposi's sarcoma in cases when there is no need for oral or intravenous medication.

This medicine is available only with your doctor's prescription.

Proper UseTOP

Avoid the use of occlusive dressings

DosingTOP

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage form (gel):
    • For cutaneous Kaposi's sarcoma:
      • Adults—Apply a generous amount to the affected area of the skin two times day, or as directed by your doctor, and allow to dry for three to five minutes before covering with clothing.
      • Children—Use and dose must be determined by your doctor.

Missed DoseTOP

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Use & StorageTOP

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

AllergiesTOP

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

PediatricTOP

Studies of this medicine have been done only in adult patients, and there is no specific information comparing the use of alitretinoin in children with use in other age groups.

GeriatricTOP

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing the use of alitretinoin in the elderly with use in other age groups.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical ProblemsTOP

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Cutaneous T-cell lymphoma—May be more likely to experience side effects of alitretinoin gel.

PrecautionsTOP

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

This medicine increases the sensitivity of the treated areas of your skin to sunlight or sun lamps. Therefore, exposure to the sun, even through window glass or on a cloudy day, could cause a serious burn.

Avoid application of the gel to normal skin surrounding the lesions or to mucous membranes

Chemical ClassificationsTOP

Retinoid
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