AFLIBERCEPT is an injectable medicine for the eye. It is used to treat wet age-related macular degeneration (AMD) and macular edema, including diabetic macular edema. This drug is also used to treat diabetic retinopathy in patients with diabetic macular edema. This medicine helps to slow the disease and may help to maintain vision. It is not a cure. Compare VEGF antibodies.

What is Aflibercept?

Commonly Used Brand Name(s)Eylea

Therapeutic ClassificationsOphthalmologic Agent




Aflibercept injection is used to treat neovascular (wet) age-related macular degeneration (AMD). AMD is a disorder of the retina in the eye that causes blurred vision or blindness. Aflibercept works by changing the amount of blood that gets to the retina.

Aflibercept injection is also used to treat macular edema after retinal vein occlusion. It is also used to treat diabetic macular edema (DME) and diabetic retinopathy in patients with DME. Macular edema is swelling in the back of the eye and may cause vision loss. Retinal vein occlusion is a blockage of a blood vessel in the eye. Swelling can occur when the blood vessel is blocked.

This medicine is to be given only by or under the direct supervision of your doctor.

Proper UseTOP

An eye doctor will give you this medicine as a shot into the eye.

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of aflibercept injection in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aflibercept injection in the elderly.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical ProblemsTOP

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood clots, history of or
  • Detached retina (eye disorder) or
  • Endophthalmitis (inflammation of the eye) or
  • Glaucoma (increased pressure in the eye)—Use with caution. May make these conditions worse.
  • Eye infection—Should not be used in patients with this condition.


Your eye doctor will want to check your progress at regular visits, especially during the first few days after you receive this medicine.

If you are a woman who can bear children, use an effective form of birth control to keep from getting pregnant during treatment and for 3 months after the last dose of this medicine. If you think you have become pregnant while using the medicine, tell your doctor right away.

Serious eye problems may occur with this medicine. Check with your eye doctor right away if your eye becomes red, sensitive to light, or painful, or if you see flashes or sparks of light, have a change in vision, or feel increased pressure in the eye several days after the injection.

This medicine may increase your risk of blood clots. Check with your doctor right away if you have pain in your chest, groin, or legs, especially the calves, difficulty with breathing, a severe, sudden headache, slurred speech, a sudden loss of coordination, severe weakness or numbness in your arm or leg, or vision changes.

This medicine may cause temporary blurred vision. Avoid driving, using machines, or doing anything else that could be dangerous if you are not able to see well.

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