Specialty Drug


EVEROLIMUS decreases the activity of your immune system. Afinitor is used to treat certain types of cancer. Zortress is used for kidney and liver transplant rejection prophylaxis. Compare kinase inhibitors.

Afinitor Side Effects

What should I watch for?

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop. Visit your doctor or health care professional for regular check-ups. You may need regular tests to monitor possible side effects of the drug.

This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.

Do not become pregnant while taking this medicine or for 8 weeks after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 2 weeks after stopping it.

This medicine has caused ovarian failure in some women. This medicine may interfere with the ability to have a child. You should talk with your doctor or health care professional if you are concerned about your fertility.

This medicine has caused reduced sperm counts in some men. This may interfere with the ability to father a child. You should talk to your doctor or health care professional if you are concerned about your fertility.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

If you have had a kidney transplant, immediately tell your doctor if your incision site is red, warm, or painful. Also, tell your doctor if your incision site opens up or swells or if contains blood, fluid, or pus.

Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Bloating or swelling of the face, arms, hands, lower legs, or feet

bloody nose

chest pain or tightness

cough or hoarseness

decreased weight


difficult or labored breathing

difficulty with swallowing

fever or chills

general feeling of discomfort or illness

lower back or side pain

painful or difficult urination

rapid weight gain

sores, ulcers, or white spots on the lips, tongue, or inside the mouth

tingling of the hands or feet

Less common

Bleeding gums

bloody urine

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

coughing up blood

extreme fatigue

fast, pounding, or irregular heartbeat or pulse

increased thirst or urination

irregular breathing

loss of appetite

nausea or vomiting



prolonged bleeding from cuts

red or black, tarry stools

red or dark brown urine

slow heartbeat



unusual tiredness or weakness

Incidence not known





hostility or irritability


muscle twitching



Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abdominal or stomach pain

change in taste

dry skin

itching skin or rash

lack or loss of strength

loss of taste

pain in the arms or legs

unable to sleep

Less common

Back pain

blistering, peeling, redness, or swelling of the palms, hands, or bottoms of the feet

bumps on the skin

burning, dry, or itching eyes

discoloration of the fingernails or toenails

flushing or redness of the skin

full feeling

jaw pain

numbness, pain, tingling, or unusual sensations in the palms of the hands or bottoms of the feet

passing gas

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

sleepiness or unusual drowsiness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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