Specialty Drug


RIOCIGUAT (rye oh sig ue at) is used to treat pulmonary hypertension. This medicine may help make exercise and breathing easier. Compare sGC stimulators.

Availability: Adempas is only available at certified specialty pharmacies. Learn More


Adempas Side Effects

What should I watch for?

Visit your doctor for regular check ups. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

This medicine can cause birth defects. Do not get pregnant while taking this drug. Females with child-bearing potential will need to have a negative pregnancy test before starting this medicine, every month while taking this medicine, and 1 month after stopping this medicine. Use 2 reliable forms of birth control together while you are taking this medicine and for 1 month after you stop taking this medicine. If you think that you might be pregnant talk to your doctor right away.

Because of the risks of birth defects, females can only receive this medicine through a special program. Doctors, pharmacies, and patients must meet all of the conditions of the program. Your health care provider will help you get signed up with the program if you need this medicine. Males do not need to participate in this program to receive this medicine.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common


dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


unusual tiredness or weakness

Less common

Abdominal or stomach pain or swelling

bloating or swelling of the face, arms, hands, lower legs, or feet

bloody or black, tarry stools

bruising or purple areas on the skin

coughing or spitting up blood

decreased alertness

fast, irregular, pounding, or racing heartbeat or pulse

heavy non-menstrual vaginal bleeding

rapid weight gain

troubled breathing with exertion

vomiting of blood or material that looks like coffee grounds

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common



heartburn or indigestion

nausea or vomiting

stuffy nose

Less common

Difficulty having a bowel movement (stool)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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